Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study
Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study
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DOI：
10.1038/s41598-020-59056-6
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发表时间：
2020-02-10
影响因子：
4.6
通讯作者：
Rinaldi, Sabina
中科院分区：
文献类型：
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作者：
His, Mathilde;Biessy, Carine;Rinaldi, Sabina
高加索女性的累积证据表明，身高与绝经前乳腺癌风险呈正相关，与总体肥胖症呈负相关；然而，来自拉丁美洲的数据很少。我们调查了来自智利、哥伦比亚、哥斯达黎加和墨西哥的406例患者(20-45岁的女性)和406例匹配的人群对照人群中过度肥胖、一生中体型演变和绝经前乳腺癌风险之间的关系。调整后的模型(体重指数(BMI)：每1 kg/m(2)的优势比(OR)=0.93；95%可信区间=0.89-0.96；腰围(WC)：每10厘米的优势比(OR)=0.81(0.69-0.96)；臀围(HC)：每10厘米的优势比(OR)=0.80(0.67-0.95))与成人肥胖和乳腺癌风险呈负相关。身高和腿长与风险无关。在正常体重的女性中(18.5
Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20-45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1kg/m(2)=0.93; 95% confidence interval=0.89-0.96; waist circumference (WC): OR per 10cm=0.81 (0.69-0.96); hip circumference (HC): OR per 10cm=0.80 (0.67-0.95)). Height and leg length were not associated with risk. In normal weight women (18.5