Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer.
Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer.
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DOI：
10.3390/molecules200610604
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发表时间：
2015-06-08
期刊：
影响因子：
--
通讯作者：
Ghiladi RA
中科院分区：
文献类型：
--
作者：
Carpenter BL;Situ X;Scholle F;Bartelmess J;Weare WW;Ghiladi RA
采用基于BODIPY的光敏剂2，6-二碘-1，3，5，7-四甲基-8-（N-甲基-4-吡啶基）-4，4 ′-二氟硼二氮并茚（DIMPy-BODIPY）的抗菌光动力灭活（aPDI）在体外试验中针对6种细菌（共8种菌株）、3种酵母菌和3种病毒进行了探索，作为其当前基于药物或不存在治疗的补充方法。我们的最佳结果是在0.1 μM浓度下，金黄色葡萄球菌（ATCC-2913）、耐甲氧西林链球菌（S.金黄色葡萄球菌（ATCC-44）和万古霉素耐药屎肠球菌（ATCC-2320），鲍曼不动杆菌ATCC-19606（0.25 μM）减少4-5个对数单位，多重耐药A.鲍曼不动杆菌ATCC-1605（0.1 μM）、铜绿假单胞菌ATCC-97（0.5 μM）和肺炎克雷伯氏菌ATCC-2146（1 μM），以及耻垢分枝杆菌mc 2155（ATCC-700084）减少3 log单位。观察到白色念珠菌ATCC-90028（1 μM）和新型隐球菌ATCC-64538（0.5 μM）的CFU减少5 log单位，光滑念珠菌ATCC-15545（1 μM）减少3 log单位。登革1型病毒（0.1 μM）的免疫力降低了6个对数单位，水泡性口炎病毒降低了5个对数单位（0.5 μM），人腺病毒-5降低了2个对数单位（5 μM）。总体而言，结果表明，DIMPy-BODIPY在纳摩尔浓度和短光照时间下表现出抗病毒、抗细菌和抗真菌的光动力学失活。
Antimicrobial photodynamic inactivation (aPDI) employing the BODIPY-based photosensitizer 2,6-diiodo-1,3,5,7-tetramethyl-8-(N-methyl-4-pyridyl)-4,4′-difluoro-boradiazaindacene (DIMPy-BODIPY) was explored in an in vitro assay against six species of bacteria (eight total strains), three species of yeast, and three viruses as a complementary approach to their current drug-based or non-existent treatments. Our best results achieved a noteworthy 5–6 log unit reduction in CFU at 0.1 μM for Staphylococcus aureus (ATCC-2913), methicillin-resistant S. aureus (ATCC-44), and vancomycin-resistant Enterococcus faecium (ATCC-2320), a 4–5 log unit reduction for Acinetobacter baumannii ATCC-19606 (0.25 μM), multidrug resistant A. baumannii ATCC-1605 (0.1 μM), Pseudomonas aeruginosa ATCC-97 (0.5 μM), and Klebsiella pneumoniae ATCC-2146 (1 μM), and a 3 log unit reduction for Mycobacterium smegmatis mc2155 (ATCC-700084). A 5 log unit reduction in CFU was observed for Candida albicans ATCC-90028 (1 μM) and Cryptococcus neoformans ATCC-64538 (0.5 μM), and a 3 log unit reduction was noted for Candida glabrata ATCC-15545 (1 μM). Infectivity was reduced by 6 log units in dengue 1 (0.1 μM), by 5 log units (0.5 μM) in vesicular stomatitis virus, and by 2 log units (5 μM) in human adenovirus-5. Overall, the results demonstrate that DIMPy-BODIPY exhibits antiviral, antibacterial and antifungal photodynamic inactivation at nanomolar concentrations and short illumination times.
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