Body weight variability in midlife and risk for dementia in old age.
Body weight variability in midlife and risk for dementia in old age.
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DOI：
10.1212/wnl.0b013e3182904cee
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发表时间：
2013-04-30
期刊：
影响因子：
9.9
通讯作者：
Goldbourt, Uri
中科院分区：
文献类型：
--
作者：
Ravona-Springer, Ramit;Schnaider-Beeri, Michal;Goldbourt, Uri
目的：分析体重变异性与30多年后痴呆的关系。方法：体重变异性的测量基于连续3次体重记录，这些记录来自参加以色列缺血性心脏病研究的10,000多名看起来健康的成年男性，其中心血管危险因素和临床状况分别在1963年、1965年和1968年进行了评估，受试者年龄在40-70岁。根据体重变化的标准差四分位数(1963/1965/1968)将男性分组：≤1.15 kg、1.16~1.73 kg、1.74~2.65 kg、≥2.66 kg。大约六分之一存活到1999年至2000年(最低年龄76岁)并接受认知评估(n=1,620)的患者在36年后被评估痴呆症的患病率。结果：在体重变化SD的第一到第四四分位数中，幸存者的痴呆症患病率分别为13.4%，18.4%，20.1%和19.2%(趋势=0.034)。多因素分析显示，与体重变化SD的第一个四分位数相比，调整了糖尿病、身高和社会经济状况后，体重变化SD的第二个四分位数的OR值分别为1.42(95%可信区间0.95-2.13)、1.59(95%可信区间1.05-2.37)和1.74(95%可信区间1.14-2.64)。这种关系与体重变化的方向无关。结论：中年体重变化可能是老年痴呆的先兆。
OBJECTIVE: To analyze the relationship between body weight variability and dementia more than 3 decades later.METHODS: The measurement of body weight variability was based on 3 successive weight recordings taken from over 10,000 apparently healthy tenured working men participating in the Israel Ischemic Heart Disease study, in which cardiovascular risk factors and clinical status were assessed in 1963, 1965, and 1968, when subjects were 40-70 years of age. Groups of men were stratified according to quartiles of SD of weight change among 3 measurements (1963/1965/1968): ≤ 1.15 kg, 1.16-1.73 kg, 1.74-2.65 kg, and ≥ 2.66 kg. The prevalence of dementia was assessed more than 36 years later in approximately one-sixth of them who survived until 1999/2000 (minimum age 76 years) and underwent cognitive evaluation (n = 1,620).RESULTS: Survivors' dementia prevalence rates were 13.4%, 18.4%, 20.1%, and 19.2% in the first to fourth quartiles of weight change SD, respectively (p for trend = 0.034). Compared to the first quartile of weight change SD and adjusted for diabetes mellitus, body height, and socioeconomic status, a multivariate analysis demonstrated that the odds ratio for dementia was 1.42 (95% confidence interval [CI] 0.95-2.13), 1.59 (95% CI 1.05-2.37), and 1.74 (95% CI 1.14-2.64) in quartiles 2-4 of weight change SD respectively. This relationship was independent of the direction of weight changes.CONCLUSION: Midlife variations in weight may antecede late-life dementia.