CAROTID-ARTERY DISEASE FOLLOWING EXTERNAL CERVICAL IRRADIATION
CAROTID-ARTERY DISEASE FOLLOWING EXTERNAL CERVICAL IRRADIATION
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DOI：
10.1097/00000658-198111000-00009
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发表时间：
1981-01-01
影响因子：
9
通讯作者：
MCMURTREY, MJ
中科院分区：
文献类型：
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作者：
ELERDING, SC;FERNANDEZ, RN;MCMURTREY, MJ
对910例霍奇金-S病、非霍奇金-S淋巴瘤和头颈部原发肿瘤患者颈部放疗后存活5年以上的910例患者进行了回顾性研究。结果表明，在平均9年的观察期内，颈部放疗后卒中的发生率为63/910。这代表了这一人群的风险比同一时期观察到的匹配人群的38例中风的预期发生率更高的趋势(P=0.39)。对118名目前在颈部放射治疗后存活5年的类似患者进行了前瞻性研究，以确定颈部放射治疗导致的颈动脉疾病的发生率。颈动脉音血管图(CPA)异常率为25%，眼压图(OPG)异常率为17%。这些研究代表了在这样的人群中没有预料到的显著的颈动脉病变。显示的颈动脉狭窄很可能是先前放疗的结果。颈部放射治疗后存活5年的患者应进行非侵入性血管实验室检查，作为常规后续检查的一部分，以便在颈动脉病变隐匿时发现它们。
A retrospective study of 910 patients surviving at least 5 yr after cervical irradiation for Hodgkin''s disease, non-Hodgkin''s lymphoma or primary head and neck neoplasms, showed the incidence of stroke following cervical irradiation was 63 of 910 patients (6.3%) during a mean period of observation of 9 yr. This represents a trend toward an increased risk for this population over the expected incidence of 38 strokes for a matched population observed over the same period of time (P = 0.39). A prospective study of 118 similar patients currently living 5 yr after cervical radiotherapy was performed to determine the incidence of carotid artery disease occurring as a consequence of neck irradiation. Abnormal carotid phonoangiograms (CPA) were found in 25% of the patients; abnormal oculoplethysmographs (OPG) were found in 17%. These studies represent significant carotid lesions that are not expected in such a population. The carotid stenoses demonstrated are most likely a consequence of prior irradiation. Patients that are 5-yr survivors of cervical irradiation should have noninvasive vascular laboratory studies performed as part of their routine follow-up examinations to detect these carotid lesions while they are occult.