Integrated mitochondria, function and cancer-related fatigue in men with prostate cancer undergoing radiation therapy
Integrated mitochondria, function and cancer-related fatigue in men with prostate cancer undergoing radiation therapy
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DOI：
10.2147/cmar.s185706
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Hoppel, Charles
中科院分区：
文献类型：
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作者：
Hsiao, Chao-Pin;Chen, Mei-Kuang;Hoppel, Charles
导语：癌症患者所经历的疲劳是最常见的症状之一，对生活质量的不利影响最大，但可以说是最不了解的。本研究旨在探讨接受局部放射治疗(XRT)的非转移性前列腺癌患者线粒体整体功能和疲劳的变化。材料和方法：我们提出了一种线粒体的生物能量学机制，即通过复合体III辐射诱导疲劳连接受损的氧化磷酸化(OXPIIOS)，并减少三磷酸腺苷(ATP)的产生。以患者外周血单核细胞线粒体OXPHOS的形式测量完整线粒体的功能。使用修订的Piper疲劳量表测量疲劳。结果：15例前列腺癌患者在XRT治疗第21天，疲乏症状加重(P
Introduction: Fatigue experienced by cancer patients is one of the most common symptoms with the greatest adverse effect on quality of life, but arguably the least understood. The purpose of this study was to explore changes in integrated mitochondrial function and fatigue in non-metastatic prostate cancer patients receiving localized radiation therapy (XRT).Materials and methods: We proposed a mitochondria' bioenergetics mechanism of radiation-induced fatigue linking impaired oxidative phosphorylation (OXPIIOS) through complex III and decreased adenosine triphosphate (ATP) production as consequences of XRT. Integrated mitochondria' function was measured as mitochondria' OXPHOS from patients' peripheral blood mononuclear cells. Fatigue was measured using the revised Piper Fatigue Scale. Data were collected before (day 0) and at day 21 of XRT.Results: At day 21 of XRT, fatigue symptom intensified in 15 prostate cancer patients (P