p53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis
p53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis
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DOI：
10.1093/carcin/bgh099
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发表时间：
2004-06-01
期刊：
影响因子：
4.7
通讯作者：
Morita, T
中科院分区：
文献类型：
--
作者：
Habu, T;Wakabayashi, N;Morita, T
抑癌蛋白p53在精母细胞减数分裂过程中特异性表达。p53基因敲除小鼠的亚群表现出睾丸巨细胞变性综合征，这表明p53可能与减数分裂细胞周期和/或DNA代谢有关。在这里，我们表明，p53结合到小鼠减数分裂特异性RecA样蛋白小鼠DMC 1（MmDMC 1）。MmDMC 1的C-末端结构域（氨基酸234-340）与p53蛋白的DNA结合结构域结合。p53可能通过与DMC 1蛋白直接结合抑制减数分裂生殖细胞基因组的不稳定性，参与同源重组和/或检查点功能。
The tumor suppressor protein p53 is specifically expressed during meiosis in spermatocytes. Subsets of p53 knockout mice exhibit testicular giant cell degenerative syndrome, which suggests p53 may be associated with meiotic cell cycle and/or DNA metabolism. Here, we show that p53 binds to the mouse meiosis-specific RecA-like protein Mus musculus DMC1 (MmDMC1). The C-terminal domain (amino acid 234-340) of MmDMC1 binds to DNA-binding domain of p53 protein. p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells.