Quality of life and personality traits in patients with malignant pleural mesothelioma and their first-degree caregivers
Quality of life and personality traits in patients with malignant pleural mesothelioma and their first-degree caregivers
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DOI：
10.2147/ndt.s48965
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发表时间：
2013-01-01
影响因子：
3.2
通讯作者：
Innamorati, Marco
中科院分区：
文献类型：
--
作者：
Granieri, Antonella;Tamburello, Stella;Innamorati, Marco
砷暴露导致严重的胸膜疾病，包括恶性胸膜间皮瘤（MPM）。考虑到MPM对情绪功能和幸福感的影响，本研究旨在通过世界卫生组织生活质量-BREF（WHOQOL-BREF）和明尼苏达多相人格问卷-2重组形式（MMPI-2-RF）评估MPM患者及其一级照顾者的生活质量和人格特质。样本由27名MPM患者、55名在Casale Monferrato和蒙法尔科内（意大利）入组的一级亲属和40名健康对照（HC）组成。患者和亲属报告的身体健康状况比HC差。与亲属和HC相比，患者有更高的身体虚弱和健康状况较差的整体感觉，更多的记忆问题和注意力集中困难的投诉，以及更大的信念，即目标无法达到或问题无法解决，同时经常声称他们比HC更优柔寡断和无效。一级亲属对他人的评价较低，更相信目标无法达到或问题无法解决，支持他们优柔寡断和无效的概念，并且更容易遭受恐惧，这大大抑制了正常活动。在多项回归分析中，部分模型表明，性别，身体合并症，和真实反应不一致性（TRIN-R），不适（MLS），行为限制性恐惧（BRF）尺寸的MMPI-2-RF组差异有显着影响。总之，卫生保健提供者应该评估MPM患者及其亲属的持续调整和情绪健康，并提供支持以减少情绪困扰。
Asbestos exposure causes significant pleural diseases, including malignant pleural mesothelioma (MPM). Taking into account the impact of MPM on emotional functioning and wellbeing, this study aimed to evaluate the quality of life and personality traits in patients with MPM and their first-degree caregivers through the World Health Organization Quality of Life-BREF (WHOQOL-BREF) and the Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF). The sample was composed of 27 MPM patients, 55 first-degree relatives enrolled in Casale Monferrato and Monfalcone (Italy), and 40 healthy controls (HC). Patients and relatives reported poorer physical health than the HC. Patients had a higher overall sense of physical debilitation and poorer health than relatives and the HC, more numerous complaints of memory problems and difficulties in concentrating, and a greater belief that goals cannot be reached or problems solved, while often claiming that they were more indecisive and inefficacious than the HC. First-degree relatives reported lower opinions of others, a greater belief that goals cannot be reached or problems solved, support for the notion that they are indecisive and inefficacious, and were more likely to suffer from fear that significantly inhibited normal activities than were HC. In multinomial regression analyses, partial models indicated that sex, physical comorbidities, and the True Response Inconsistency (TRIN-r), Malaise (MLS), and Behavior-Restricting Fears (BRF) dimensions of the MMPI-2-RF had significant effects on group differences. In conclusion, health care providers should assess the ongoing adjustment and emotional wellbeing of people with MPM and their relatives, and provide support to reduce emotional distress.