Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview.

Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview.
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邻苯二甲酸二-2-乙基己酯的毒性作用:概述

DOI:
10.1155/2018/1750368
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发表时间:
2018
影响因子:
--
通讯作者:
Chen J
Chen J
中科院分区:
生物学3区
文献类型:
--
作者:
Rowdhwal SSS;Chen J

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邻苯二甲酸二(2-乙基己基)酯(DEHP)作为增塑剂广泛用于许多产品中,特别是医疗器械、家具材料、化妆品和个人护理产品。DEHP与塑料非共价结合,因此,在重复使用、加热和/或清洁产品后,DEHP将从这些产品中浸出。由于DEHP在许多产品中的过度使用,它通过从工业环境和塑料废物处理场释放进入并污染环境。DEHP可以通过每天吸入、摄入和皮肤接触进入人体,这引起了人们对其安全性及其对人类健康的潜在影响的担忧。本综述的主要目的是概述DEHP在体外和体内对动物模型和人体的内分泌、睾丸、卵巢、神经、肝脏毒性和心脏毒性作用。
Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo.
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