Association of Indoxyl Sulfate with Heart Failure among Patients on Hemodialysis
Association of Indoxyl Sulfate with Heart Failure among Patients on Hemodialysis
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DOI：
10.2215/cjn.04730514
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发表时间：
2015-01-01
影响因子：
9.8
通讯作者：
Ding, Xiao-Qiang
中科院分区：
文献类型：
--
作者：
Cao, Xue-Sen;Chen, Jun;Ding, Xiao-Qiang
背景和目的硫代吲哚是一种蛋白结合的尿毒症毒素，可能与慢性肾脏病患者的心血管事件和死亡率有关。本研究旨在探讨硫代吲哚与血液透析患者心力衰竭的关系。设计、设置、参与者和测量。研究前3个月内有充血性心力衰竭、心绞痛、急性心肌梗死、脑梗塞或脑出血的患者，或32.35g/ml)。然后，对患者进行前瞻性随访，中位数为48.0个月(四分位数范围：33.5-48.0个月)。在随访期间，68名患者经历了首次心力衰竭发作。Kaplan-Meier分析显示，高吲哚基硫酸酯组首次心力衰竭事件的发生率显著高于低吲哚基硫酸酯组(对数等级P
Background and objectivesIndoxyl sulfate, a protein-bound uremic toxin, may be associated with cardiovascular events and mortality in patients with CKD. This study aimed to investigate the relationship between indoxyl sulfate and heart failure in patients on hemodialysis.Design, setting, participants, & measurementsPatients on hemodialysis for >6 months were enrolled within 6 months. Patients with congestive heart failure, angina pectoris, acute myocardial infarction, cerebral infarction, or cerebral hemorrhage within 3 months before the study or those 32.35 g/ml). Then, patients were prospectively followed up for a median of 48.0 (interquartile range: 33.5-48.0) months. During follow-up, 68 patients experienced episodes of first heart failure. Kaplan-Meier analysis revealed the incidence of first heart failure event in the high-indoxyl sulfate group was significantly higher than in the low-indoxyl sulfate group (log rank P