Probable Parasomnias and Mortality: A Prospective Study in US Men.
Probable Parasomnias and Mortality: A Prospective Study in US Men.
复制标题
可能的异态睡眠和死亡率：对美国男性的前瞻性研究。
DOI：
10.1016/j.mayocp.2023.06.018
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发表时间：
2023
影响因子：
8.9
通讯作者：
Gao,Xiang
中科院分区：
文献类型：
--
作者：
Zhang,Xinyuan;Molsberry,SamanthaA;Pavlova,Milena;Schwarzschild,MichaelA;Ascherio,Alberto;Gao,Xiang
ObjectiveTo探讨异眠症（包括快速眼动睡眠行为障碍（RBD）和梦游（SW））与大规模人群队列中死亡风险之间的相关性。MethodsThis前瞻性队列研究基于25，695名健康专业人员随访研究（Health Professionals Follow-up Study）的参与者，这是一项以人群为基础的美国男性健康专业人员队列研究。通过改编自2012年马约睡眠问卷的问题测量可能SW（pSW）和可能RBD（pRBD）。从2012年1月1日至2018年6月30日，通过国家登记处、家庭报告和邮政系统确定全因死亡率和特定原因死亡率。在6年的随访期间（2012年至2018年），记录了4743例死亡病例。两种可能的异眠症的同时发生与更高的全因死亡风险相关（Ptrend=.008），在调整主要生活方式、睡眠和代谢危险因素以及慢性疾病后，与没有任何一种可能的异眠症的参与者相比，死亡率的调整风险比（HR）为1.65（95%CI，1.20至2.28）。发现神经退行性疾病导致的死亡率（两种异眠症与无异眠症的校正HR为4.57; 95%CI为2.62 - 7.97）和意外事件（两种异眠症与无异眠症的校正HR为7.36; 95%CI为2.95 - 18.4）存在显著相关性。pSW单独与全因死亡率相关，pSW和pRBD单独与神经退行性疾病和事故的死亡率相关（P<0.05）。
ObjectiveTo examine the association between parasomnias, including rapid eye movement sleep behavior disorder (RBD) and sleep walking (SW), and mortality risk in a large-scale population-based cohort.MethodsThis prospective cohort study was based on 25,695 participants from the Health Professionals Follow-up Study, a population-based cohort of male health professionals in the United States. Probable SW (pSW) and probable RBD (pRBD) were measured by questions adapted from the Mayo Sleep Questionnaire in 2012. All-cause mortality and cause-specific mortality were ascertained through the national registry, reports by the families, and the postal system from January 1, 2012, through June 30, 2018.ResultsOf the studied population, 223 reported pSW and 2720 reported pRBD. During 6 years of follow-up (2012 to 2018), 4743 mortality cases were documented. The co-occurrence of both probable parasomnias was associated with higher all-cause mortality risk (Ptrend=.008), and the adjusted hazard ratio (HR) of mortality was 1.65 (95% CI, 1.20 to 2.28) compared with participants without either probable parasomnia after adjustment for major lifestyle, sleep, and metabolic risk factors, and chronic diseases. Significant associations were found for mortality attributed to neurodegenerative diseases (adjusted HR for both parasomnias vs none, 4.57; 95% CI, 2.62 to 7.97) and accidents (adjusted HR for both parasomnias vs none, 7.36; 95% CI, 2.95 to 18.4). Having pSW alone was associated with all-cause mortality, and pSW and pRBD were individually associated with mortality attributed to neurodegenerative diseases and accidents too (P<.05 for all).ConclusionProbable parasomnia was associated with a higher risk of all-cause mortality and mortality attributed to neurodegenerative diseases and accidents.