2-arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice
2-arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice
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DOI：
10.1016/s0014-2999(00)00653-1
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发表时间：
2000-10-06
影响因子：
5
通讯作者：
Mechoulam, R
中科院分区：
文献类型：
--
作者：
Gallily, R;Breuer, A;Mechoulam, R
2-Arachidonylglycerol (2-AG) 在体外抑制小鼠巨噬细胞以及小鼠体内肿瘤坏死因子-α (TNF-α) 的产生。它对一氧化氮（NO）的产生没有影响。当 2-AG 与 2-亚油基甘油 (2-Lino-G) 和 2-棕榈基甘油 (2-PalmG) 一起施用时，对 TNF-α 的作用会增强，这是先前在一些行为和结合测定中注意到的“随行效应”。 2-AG 还抑制自由基氧中间体的形成。 (C) 2000 Elsevier Science B.V. 保留所有权利。
2-Arachidonylglycerol (2-AG) inhibits the production in Vitro of tumor necrosis factor-alpha (TNF-alpha) by mouse macrophages, as well as in mice. It has no effect on the production of nitric oxide (NO). The effect on TNF-alpha is enhanced when 2-AG is administered together with 2-linoleylglycerol (2-Lino-G) and 2-palmitylglycerol (2-PalmG), an 'entourage effect' previously noted in several behavioral and binding assays. 2-AG also suppresses the formation of radical oxygen intermediates. (C) 2000 Elsevier Science B.V. All rights reserved.