CONDUCTION-VELOCITY IS RELATED TO MORPHOLOGICAL CELL TYPE IN RAT DORSAL-ROOT GANGLION NEURONS
CONDUCTION-VELOCITY IS RELATED TO MORPHOLOGICAL CELL TYPE IN RAT DORSAL-ROOT GANGLION NEURONS
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DOI：
10.1113/jphysiol.1985.sp015573
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发表时间：
1985-01-01
影响因子：
5.5
通讯作者：
LAWSON, SN
中科院分区：
文献类型：
--
作者：
HARPER, AA;LAWSON, SN
结合细胞内记录和染料注射技术允许直接相关的神经元索马大小与周围神经传导速度在个别神经元的[腰] L4背根神经节（DRG）的麻醉5 - 8周龄大鼠。传导速度分为2个主要组;> 14 m/s的组（A α.和β纤维）和那些<8 m/s（A. C纤维）。传导速度为A δ的纤维在坐骨神经中，在坐骨切迹和DRG中的神经元索马之间的范围（2.2 - 8 m/s）通常传导得更慢，即在从胫神经到坐骨切迹的外周中的C纤维范围（<1.4 m/s）。对于快速传导的有髓鞘传入，在细胞大小和外周轴突的传导速度之间存在松散的正相关，而对于A δ-1和A δ-2，在神经元细胞大小和轴突传导速度之间存在更清楚的正相关。和C纤维传入神经。对于不同的传导速度组，每个神经元索马的细胞横截面积（在核仁水平测量）与细胞体积的关系相似。快速传导的有髓鞘A α的胞体。和A.纤维具有与大的光细胞群相似的横截面积的平均值和范围。A. δ. C纤维大小较均匀，局限于神经节内较小的细胞内。C细胞的横截面积的平均值和范围与小暗细胞群的横截面积的平均值和范围相似。A.delta.胞体的细胞大小的平均值和范围比小的暗细胞群体的细胞大小的平均值和范围大。本文还讨论了外周轴突类型与细胞形态的关系。
Combining intracellular recording and dye-injection techniques permitted direct correlation of neuronal soma size with peripheral nerve conduction velocity in individual neurons of the [lumbar] L4 dorsal root ganglion (DRG) of the anesthetized 5-8-wk-old rat. The conduction velocities fell into 2 main groups; those > 14 m/s (A.alpha. and .beta. fibers) and those < 8 m/s (A.delta. and C fibers). Fibers with conduction velocities in the A.delta. range (2.2-8 m/s) in the sciatic nerve between the sciatic notch and the neuronal soma in the DRG often conducted more slowly, that is in the C-fiber range (< 1.4 m/s), in the periphery from the tibial nerve to the sciatic notch. For the fast-conducting myelinated afferents, there was a loose positive correlation between cell size and the conduction velocity of the peripheral axon, whereas a clearer positive correlation existed between neuronal cell size and axonal conduction velocity both for A.delta.- and for C-fiber afferents. The relationship of the cell cross-sectional area (measured at the nucleolar level), to the cell volume for each neuronal soma was similar for the different conduction velocity groups. The somata of the fast-conducting myelinated A.alpha. and A.beta. fibers had a similar mean and range of cross-sectional areas to those of the large light cell population. The somata with A.delta. and C fibers were of a more uniform size and were restricted to the smaller cells within the ganglia. The mean and range of cross-sectional areas of the C cells was similar to those of the small dark cell population. A.delta. somata had a larger mean and range of cell sizes than those of the small dark cell population. The relationships of peripheral axon type to the morphological cell types are discussed.