IMPROVE-BMT: a protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients.
IMPROVE-BMT: a protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients.
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DOI：
10.1136/bmjopen-2022-066841
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发表时间：
2023-01-18
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
成人造血干细胞移植(HSCT)是一种治疗多种血液系统恶性肿瘤的强化治疗方法。虽然有大量证据表明HSCT对身体功能和心理社会参数的负面影响，但关于HSCT对身体成分和骨健康的影响的证据有限。此外，旨在改善身体功能和患者报告结果的有氧和阻力训练运动干预主要发生在移植围手术期和移植后。康复锻炼，或医疗前锻炼，已经成功地应用于手术前候选人和其他肿瘤部位，但关于HSCT患者康复效果的证据很少。本研究的目的是探讨恶性血液病患者在HSCT前进行抵抗力训练的可行性、可接受性和安全性。通过运动康复对肿瘤学的影响-骨髓移植是一项与常规护理相比的运动干预的单一地点、试点随机对照试验。主要目的是评估HSCT前阻力训练训练干预的可行性、可接受性和安全性。次要目标包括评估运动组和常规护理对照组在身体功能、身体成分、骨密度和患者报告的结果方面的差异。结果测量将被评估：在HSCT前、HSCT入院当天或前后、HSCT后30天和HSCT后100天。运动干预是一项以家庭为基础的阻力训练运动计划，包括阻力带和体重练习。主要结果将以百分比和/或平均值报告。将使用适当的统计方法对次要结果进行分析，以描绘组内和组间差异。这项研究得到了宾夕法尼亚州立医学院的批准。结果将通过科学出版物传播，并在与运动和肿瘤学有关的科学会议上介绍。NCT03886909。
Haematopoietic stem cell transplant (HSCT) in adults is an intensive medical procedure for a variety of haematological malignancies. Although there is a large body of evidence demonstrating the negative effects of HSCT on physical function and psychosocial parameters, there is limited evidence on the impact of HSCT on body composition and bone health. Further, aerobic and resistance-training exercise interventions aimed at improving physical function and patient-reported outcomes largely take place during the peritransplant and post-transplant period. Prehabilitative exercise, or exercise prior to medical treatment, has been successfully deployed in presurgical candidates and other tumour sites, yet there is a paucity of evidence on the effect of prehabilitation in HSCT patients. The aim of this study is to investigate the feasibility, acceptability and safety of a resistance training exercise programme in patients with haematological malignancies prior to HSCT. IMpact of PRehabilitation in Oncology Via Exercise-Bone Marrow Transplant is a single-site, pilot randomised controlled trial of an exercise intervention compared with usual care. The primary aim is to assess the feasibility, acceptability and safety of the resistance-training exercise intervention prior to HSCT. Secondary aims include evaluating the differences in physical function, body composition, bone mineral density and patient-reported outcomes between the exercise group and usual care control group. Outcome measurements will be assessed: prior to HSCT, on/around day of HSCT admission, +30 days post-HSCT and +100 days post-HSCT. The exercise intervention is a home-based resistance training exercise programme that incorporates resistance band and body weight exercises. The primary outcomes will be reported as percentages and/or mean values. The secondary outcomes will be analysed using appropriate statistical methods to portray within-group and between-group differences. The study has Penn State College of Medicine approval. Results will be disseminated through scientific publication and presentation at exercise-related and oncology-related scientific meetings. NCT03886909.
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影响因子：
28.4
作者：
Dueck AC;Mendoza TR;Mitchell SA;Reeve BB;Castro KM;Rogak LJ;Atkinson TM;Bennett AV;Denicoff AM;O'Mara AM;Li Y;Clauser SB;Bryant DM;Bearden JD 3rd;Gillis TA;Harness JK;Siegel RD;Paul DB;Cleeland CS;Schrag D;Sloan JA;Abernethy AP;Bruner DW;Minasian LM;Basch E;National Cancer Institute PRO-CTCAE Study Group
通讯作者：
National Cancer Institute PRO-CTCAE Study Group
影响因子：
2.9
作者：
Keen C;Skilbeck J;Ross H;Smith L;Collins K;Dixey J;Walters S;Greenfield DM;Snowden JA;Mawson S
通讯作者：
Mawson S
影响因子：
4.3
作者：
DeFilipp, Zachariah;Troschel, Fabian M.;Fintelmann, Florian J.
通讯作者：
Fintelmann, Florian J.
影响因子：
4.7
作者：
Hann, D;Winter, K;Jacobsen, P
通讯作者：
Jacobsen, P
影响因子：
11.3
作者：
BUYSSE, DJ;REYNOLDS, CF;KUPFER, DJ
通讯作者：
KUPFER, DJ