Parent child interaction and oxytocin production in pre-schoolers with autism spectrum disorder
Parent child interaction and oxytocin production in pre-schoolers with autism spectrum disorder
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DOI：
10.1192/bjp.bp.113.137513
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发表时间：
2014-08-01
影响因子：
10.5
通讯作者：
Zagoory-Sharon, Orna
中科院分区：
文献类型：
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作者：
Feldman, Ruth;Golan, Ofer;Zagoory-Sharon, Orna
背景孤独症谱系障碍（ASD）与催产素系统的遗传风险有关，这表明催产素参与ASD;但催产素在幼儿ASD中的功能是未知的。目的是评估基线催产素在学龄前儿童ASD和测试是否催产素的生产可能会增强由父母-孩子contact.Method 40学龄前儿童与高功能ASD匹配。典型地开发控件。两次家访包括一次相同的45分钟社交电池，一次是母亲，一次是父亲。四个唾液催产素样本收集每个父母和孩子在每次visit.Results ASD儿童有较低的基线催产素。经过20毫米的亲子互动，催产素正常化，并保持在社会接触高。十五接触后10分钟，催产素下降到基线水平。结论ASD患儿在儿童早期存在催产素功能障碍。亲子接触后催产素产生的快速改善强调了该系统的可塑性，并为基于依恋的行为和药物干预指明了未来的方向。
Background Autism spectrum disorder (ASD) is associated with genetic risk on the oxytocin,system, suggesting oxytocin involvement in ASD; yet oxytocin functioning in young children with ASD is unknown.Aims To assess baseline oxytocin in pre-schoolers with ASD and test whether oxytocin production may be enhanced by parent-child contact.Method Forty pre-schoolers with high-functioning ASD were matched with 40. typically developing controls. Two home visits included an identical 45-minute social battery once with the mother and once with the father. Four saliva oxytocin samples were collected from each parent and the child during each visit.Results Children with ASD had lower baseline oxytocin. Following 20 mm of parent-child interactions, oxytocin normalised and remained high during social contact. Fifteen. minutes after contact, oxytocin fell to baseline. Oxytocin correlated with parent-child social synchrony in both groups.Conclusions Oxytocin dysfunction in ASD is observed in early childhood. The quick improvement in oxytocin production following parent-child contact underscores the malleability of the system and charts future directions for attachment-based behavioural and pharmacological interventions.