Is bone loss after gastric bypass surgery associated with the extent of weight loss?
Is bone loss after gastric bypass surgery associated with the extent of weight loss?
复制标题
胃绕道手术后骨质流失与体重减轻程度有关吗？
DOI：
10.1038/ncpendmet1043
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发表时间：
2009
影响因子：
--
通讯作者：
Shapses,SueA
中科院分区：
文献类型：
--
作者：
Shapses,SueA
这篇实践点评论讨论了Fleisheret等人的一项前瞻性研究，该研究显示23名患者在Roux-en-Y胃旁路手术后极度体重减轻引起骨丢失。髋部BMD的下降与体重减轻的程度成正比，而脊柱或桡骨远端BMD的下降与体重减轻的程度无关。虽然术后膳食钙和维生素D摄入量明显增加，但血清25羟维生素D、血清甲状旁腺激素和尿钙水平仍保持在术前水平。在这里，我强调了与严重减肥相关的骨质流失问题，讨论了在热量限制期间可能改变骨调节的机制，并考虑如何使用饮食来预防减肥手术后的骨质疏松症。
This Practice Point commentary discusses a prospective study by Fleisheret al. that showed bone loss in response to extreme weight loss in 23 patients following Roux-en-Y gastric bypass surgery. The decline in BMD at the hip, but not at the spine or distal radius, was found to be proportional to the extent of weight loss. Although dietary calcium and vitamin D intake markedly increased after surgery, serum 25 hydroxyvitamin D, serum parathyroid hormone and urinary calcium levels remained at presurgery levels. Here, I highlight concerns about bone loss associated with severe weight loss, discuss mechanisms that might alter bone regulation during caloric restriction, and consider how diet might be used to prevent osteoporosis after weight-loss surgery.