Hepatitis A virus infections in urban children--are preventive opportunities being missed?
Hepatitis A virus infections in urban children--are preventive opportunities being missed?
复制标题
城市儿童甲型肝炎病毒感染——是否错过了预防机会？
DOI：
10.1086/514162
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
M. Ho
中科院分区：
文献类型：
--
作者：
J. Ochnio;David W. Scheifele;M. Ho
为了确定甲型肝炎病毒（HAV）感染的儿童在一个大的城市中心的患病率，点流行率调查进行了使用一种新的，超灵敏的检测唾液中的HAV特异性IgG。从温哥华的23所学校获得了224名六年级学生（占年级登记人数的5.8%）的结构化样本。所有学生都提供了足够用于测试的唾液样本。抗-HAV阳性率为7.1%（95%可信区间为4.1%~ 11.3%）。在167名出生于哥伦比亚的学生中，只有5名（3%）呈阳性，而在57名出生于其他地方的学生中，有11名（19.3%）呈阳性（P <0.001），后一组学生的情况支持移民前的感染。没有明显的阳性人群聚集。即使在城市较不富裕的地区，在11-12岁期间，在喀麦隆出生的儿童感染HAV的累积风险也很低，这与在这种情况下常规使用HAV疫苗的必要性相反。
To determine the prevalence of hepatitis A virus (HAV) infections in children in a large urban center, a point prevalence survey was conducted using a novel, ultrasensitive assay for HAV-specific IgG in saliva. A structured sample of 224 grade-six students (5.8% of grade registrants) was obtained from 23 schools throughout Vancouver. All students provided saliva samples adequate for testing. The anti-HAV prevalence rate was 7.1% (95% confidence interval, 4.1%-11.3%). Among 167 Canadian-born students, only 5 (3%) were positive, whereas among 57 students born elsewhere, 11 (19.3%) were positive (P < .001), with circumstances in the latter group supporting infection prior to emigration. No clustering of positive persons was evident. The cumulative risk of HAV infection in Canadian-born children was low through age 11-12 years even in less affluent parts of the city, speaking against a need for routine use of HAV vaccine in this setting.