Medial temporal lobe damage causes deficits in episodic memory and episodic future thinking not attributable to deficits in narrative construction.
Medial temporal lobe damage causes deficits in episodic memory and episodic future thinking not attributable to deficits in narrative construction.
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DOI：
10.1523/jneurosci.1145-11.2011
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发表时间：
2011-07-13
期刊：
影响因子：
--
通讯作者：
Verfaellie M
中科院分区：
文献类型：
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作者：
Race E;Keane MM;Verfaellie M
内侧颞叶（MTL）对情景记忆做出了重要贡献，但其对情景未来思维的贡献仍然存在争议。一种观点认为，想象未来事件依赖于MTL机制，该机制也支持对过去事件的记忆。另外，最近有人提出，未来的思维是独立的MTL介导的过程，可以支持MTL以外的地区。本研究探讨了MTL参与想象未来的性质和必要性，并验证了MTL通过支持与叙事构建相关的在线绑定过程来促进未来思维的新假设。具有良好特征的MTL损伤的人类健忘症患者和健康对照组构建了关于（a）未来事件，（B）过去事件和（c）视觉呈现的图片的叙述。虽然这三项任务对叙事结构的要求都很相似，但只有过去和未来的条件需要记忆/未来思维来在心理上产生相关的叙事信息。患者对过去和未来事件的描述都很贫乏，但在产生详细的图片叙述方面没有受损。此外，未来思维表现与情景记忆表现呈正相关，但与图片叙事表现无关。最后，当MTL病变仅限于海马并且不依赖于MTL外神经损伤的存在时，未来思维障碍存在。这些结果表明，产生和保持一个详细的叙述的能力是保存在健忘症，并建议一个共同的MTL机制支持情节记忆和情节未来的思维。
The medial temporal lobe (MTL) makes critical contributions to episodic memory, but its contributions to episodic future thinking remain a matter of debate. By one view, imagining future events relies on MTL mechanisms that also support memory for past events. Alternatively, it has recently been suggested that future thinking is independent of MTL-mediated processes and can be supported by regions outside the MTL. The current study investigated the nature and necessity of MTL involvement in imagining the future and tested the novel hypothesis that the MTL contributes to future thinking by supporting online binding processes related to narrative construction. Human amnesic patients with well-characterized MTL damage and healthy controls constructed narratives about (a) future events, (b) past events, and (c) visually-presented pictures. While all three tasks place similar demands on narrative construction, only the past and future conditions require memory/future thinking to mentally generate relevant narrative information. Patients produced impoverished descriptions of both past and future events but were unimpaired at producing detailed picture narratives. In addition, future-thinking performance positively correlated with episodic memory performance but did not correlate with picture narrative performance. Finally, future-thinking impairments were present when MTL lesions were restricted to the hippocampus and did not depend on the presence of neural damage outside the MTL. These results indicate that the ability to generate and maintain a detailed narrative is preserved in amnesia and suggest that a common MTL mechanism supports both episodic memory and episodic future thinking.