DIAGNOSIS OF DEMENTIAS USING PARTIAL LEAST-SQUARES DISCRIMINANT-ANALYSIS
DIAGNOSIS OF DEMENTIAS USING PARTIAL LEAST-SQUARES DISCRIMINANT-ANALYSIS
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DOI：
10.1159/000106926
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发表时间：
1995-03-01
期刊：
影响因子：
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通讯作者：
GOTTFRIES, CG
中科院分区：
文献类型：
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作者：
GOTTFRIES, J;BLENNOW, K;GOTTFRIES, CG
本文对20例Alzheimer病（AD）、34例Alzheimer型老年性痴呆（SDAT）和12例血管性痴呆（VAD）患者进行了详细的研究。根据DSM-III-R标准进行诊断，AD/SDAT也根据NINCDS-ADRDA标准进行诊断。数据集由检查时获得的29个描述符变量组成，并将数据拟合至使用虚拟变量作为响应变量（即临床诊断）的偏最小二乘模型。在描述变量空间上的分数分布显示了对所有三种诊断的充分分类，SDAT和AD之间以及VAD和SDAT之间存在一些重叠。该研究表明，AD和SDAT之间的痴呆学存在明显差异，不受年龄本身或痴呆严重程度的影响。
Twenty patients with Alzheimer's disease (AD), 34 with senile dementia of the Alzheimer type (SDAT) and 12 with vascular dementia (VAD) were carefully investigated. The diagnoses were made according to the DSM-III-R criteria and for AD/SDAT also according to the NINCDS-ADRDA criteria. The data set consisted of 29 descriptor variables obtained at the examination, and the data were fitted to a partial least squares model using dummy variables for the response variables (i.e. clinical diagnoses). The distribution of the scores over the descriptor variable space revealed adequate classification regarding all three diagnoses, with some overlap between SDAT and AD and between VAD and SDAT. The study demonstrates a clear difference in symptomatology between AD and SDAT with no influence of age per se or the severity of dementia.