ROBUST FEEDING FOLLOWING CENTRAL ADMINISTRATION OF NEUROPEPTIDE-Y OR PEPTIDE-YY IN CHICKS, GALLUS-DOMESTICUS
ROBUST FEEDING FOLLOWING CENTRAL ADMINISTRATION OF NEUROPEPTIDE-Y OR PEPTIDE-YY IN CHICKS, GALLUS-DOMESTICUS
复制标题
DOI：
10.1016/0196-9781(87)90066-0
复制
发表时间：
1987-09-01
期刊：
影响因子：
3
通讯作者：
DAVISON, BA
中科院分区：
文献类型：
--
作者：
KUENZEL, WJ;DOUGLASS, LW;DAVISON, BA
将神经肽Y（NPY）和肽YY（PYY）注入肉鸡脑室内（ICV）。与生理盐水（SAL）对照组相比，NPY和PYY在注射后第一个小时内显著增加食物摄入。在给予5 μ g NPY的雏鸡中食物摄入加倍。响应面分析表明，在ICV注射NPY后，使用9 μ g的剂量发生最大食物摄入。相反，1 - 5 μ g PYY的估计剂量导致最大食物摄入，给予后者略高的效力。NPY组、PYY组和SAL组的饮酒时间无显著差异。与对照组相比，给予NPY或PYY的鸡站立的时间也显著减少，而给予PYY的鸡梳理羽毛的时间显著减少。
Neuropeptide Y (NPY) and peptide YY (PYY) were injected intracerebroventricularly (ICV) in broiler chicks. Both NPY and PYY markedly increased food intake during the first hour post-injection compared to saline (SAL) controls. Food intake doubled in chicks given 5 .mu.g NPY. A response surface analysis suggested that following ICV injection of NPY, maximum food intake occurred, using a dose of 9 .mu.g. In contrast, an estimated dose between one and 5 .mu.g PYY resulted in maximum food intake, giving the latter a slightly higher potency. Time spent drinking was not significantly different among NPY, PYY and SAL groups. Chicks given NPY or PYY also spent significantly less time standing while those given PYY spent significantly less time preening compared to controls.