Solving the lost in translation problem: Improving the effectiveness of translational research
Solving the lost in translation problem: Improving the effectiveness of translational research
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DOI：
10.1016/j.coph.2012.08.005
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发表时间：
2013-02-01
影响因子：
4
通讯作者：
Levin, Leonard A.
中科院分区：
文献类型：
--
作者：
Ergorul, Ceren;Levin, Leonard A.
转化研究经常无法在临床上复制实验室中已经证明的东西。这对于中枢神经系统的神经保护、青光眼的神经保护以及许多其他医学领域都是如此。这种“翻译中的迷失”问题的两个根本原因是“蝴蝶效应”（许多动物模型的混乱行为）和两种文化问题（临床前和临床研究方法之间的差异）。我们提出了几种策略来处理这些问题，包括使用动物模型的集合，在临床前神经保护研究中增加眼内压降低，改变临床前研究的方式，以及增加临床前和临床团队之间的互动。
Translational research frequently fails to replicate in the clinic what has been demonstrated in the laboratory. This has been true for neuroprotection in the central nervous system, neuroprotection in glaucoma, as well as many other areas of medicine. Two fundamental reasons for this 'Lost in Translation' problem are the 'Butterfly Effect' (chaotic behavior of many animal models) and the Two Cultures' problem (differences between the methodologies for preclinical and clinical research). We propose several strategies to deal with these issues, including the use of ensembles of animal models, adding intraocular pressure lowering to preclinical neuroprotection studies, changing the way in which preclinical research is done, and increasing interactions between the preclinical and clinical teams.