Turning it up a Notch: cross-talk between TGF beta and Notch signaling.
Turning it up a Notch: cross-talk between TGF beta and Notch signaling.
复制标题
DOI：
--
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
M. Klüppel;J. Wrana
中科院分区：
文献类型：
--
作者：
M. Klüppel;J. Wrana
通过生长因子的转化生长因子β（TGF β）超家族和Notch两者的信号传导在胚胎模式形成和细胞命运决定期间起关键作用。虽然这两种途径能够在某些细胞类型中发挥类似的生物学反应，但尚未描述这两种信号传导途径之间的功能性相互作用。现在，三篇论文提供了TGF β和Notch信号之间协同作用和拮抗作用的证据。这些报道描述了在TGF β和BMP诱导的Notch靶基因表达中以及在BMP控制的细胞分化和迁移中对Notch信号转导的需要。这些论文揭示了Notch和TGF β通路之间的直接联系，并表明Notch在TGF β家族信号传导的一些生物反应中起着关键作用。
Signaling through both the transforming growth factor beta (TGF beta) superfamily of growth factors and Notch play crucial roles during embryonic pattern formation and cell fate determination. Although both pathways are able to exert similar biological responses in certain cell types, a functional interaction between these two signaling pathways has not been described. Now, three papers provide evidence of both synergy and antagonism between TGF beta and Notch signaling. These reports describe a requirement for Notch signal transducers in TGF beta- and BMP-induced expression of Notch target genes, as well as in BMP-controlled cell differentiation and migration. These papers uncover a direct link between the Notch and TGF beta pathways and suggest a critical role for Notch in some of the biological responses to TGF beta family signaling.