Densification of Diazonium-Based Organic Thin Film as Bioelectrical Interface
Densification of Diazonium-Based Organic Thin Film as Bioelectrical Interface
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作为生物电界面的重氮基有机薄膜的致密化
DOI：
10.1021/acs.langmuir.1c02291
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发表时间：
2021
期刊：
影响因子：
3.9
通讯作者：
Sakata Toshiya
中科院分区：
文献类型：
--
作者：
Nishitani Shoichi;Fukuma Toru;Himori Shogo;Man Youyuan;Shiratori Reiko;Sakata Toshiya
芳基重氮化学在各种材料上产生共价附着的薄膜。由于薄膜的稳定性、易于功能化和多功能性，这种化学物质具有多种应用。然而，不受控制地生长成聚芳基薄膜限制了薄膜有益性能的可控性。在这项研究中，我们开发了一种多步骤接枝协议，以增加薄膜的密度，同时保持纳米级的厚度。这种简单的方法使硝基苯聚芳基膜完全钝化，完全消除了表面的电化学反应。然后，我们将该方案应用于苯磷胆碱膜的接枝，其致密化显著提高了膜的防污性能。结合其精确控制功能化表面密度的潜力，我们相信这种接枝方法将在生物电气界面的开发中得到应用。
Aryl diazonium chemistry generates a covalently attached thin film on various materials. This chemistry has diverse applications owing to the stability, ease of functionalization, and versatility of the film. However, the uncontrolled growth into a polyaryl film has limited the controllability of the film’s beneficial properties. In this study, we developed a multistep grafting protocol to densify the film while maintaining a thickness on the order of nanometers. This simple protocol enabled the full passivation of a nitrophenyl polyaryl film, completely eliminating the electrochemical reactions at the surface. We then applied this protocol to the grafting of phenylphosphorylcholine films, with which the densification significantly enhanced the antifouling property of the film. Together with its potential to precisely control the density of functionalized surfaces, we believe this grafting procedure will have applications in the development of bioelectrical interfaces.