ABDOMINAL CONSTRICTION RESPONSE AND ITS SUPPRESSION BY ANALGESIC DRUGS IN MOUSE
ABDOMINAL CONSTRICTION RESPONSE AND ITS SUPPRESSION BY ANALGESIC DRUGS IN MOUSE
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DOI：
10.1111/j.1476-5381.1968.tb00973.x
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发表时间：
1968-01-01
影响因子：
7.3
通讯作者：
SCHNEIDER, C
中科院分区：
文献类型：
--
作者：
COLLIER, HOJ;DINNEEN, LC;SCHNEIDER, C
在31种物质中，当腹腔内注射到T.O.品系小鼠，26只在10秒内有效。在30秒内有显著的反应发生率。乙酰胆碱、三磷酸腺苷、缓激肽、组胺、5-羟色胺、2.5%KCl溶液、4%NaCl溶液或色胺等12种物质。在对乙酸、1.8%CaCl2溶液、氯丁醇、5-羟基色氨酸、2%硫酸镁溶液、苯基苯醌或色氨酸的反应开始前有较长的延迟。对于最大有效剂量的乙酰胆碱、ATP、缓激肽、KCl或色胺，70%或更多的小鼠在2分钟内有反应。2-4分钟后，答复率下降。测试了10种镇痛药物在腹膜内注射5种激发物质中的至少4种后2分钟内降低腹部收缩反应发生率的能力。可待因、吗啡、环唑辛、纳洛啡、喷他佐辛、阿司匹林、氟芬那酯、甲氨萘酯和甲芬那酯对这些激发物质有不同程度的有效性。扑热息痛仅对乙酰胆碱有效。所有的解热药，但没有麻醉或麻醉拮抗剂药物，对乙酰胆碱比对色胺挑战更有效。81种药物作为乙酰胆碱引起的腹部收缩的拮抗剂进行了测试。所有在人中具有镇痛活性的化合物在小鼠中均有效。27种镇痛药中，有极显著性差异（P
Of 31 substances tested for ability to elicit abdominal constriction (writhing) responses when injected intraperitoneally into T.O. strain mice, 26 were effective within 10 sec. to 30 min. There was a significant incidence of responses within 30 sec. of injecting each of 12 substances, including acetylcholine, adenosine triphosphate, bradykinin, histamine, 5-hydroxytryptamine, 2.5% KC1 solution, 4% NaCl solution or tryptamine. There was a longer delay before the onset of responses to acetic acid, 1.8% CaCl2 solution, chlorbutol, 5-hydroxytryptophan, 2% magnesium sulphate solution, phenylbenzoquinone or tryptophan. To maximally effective intraperitoneal doses of acetylcholine, ATP, bradykinin, KC1 or tryptamine, 70% or more mice responded within 2 min. After 2-4 min., the incidence of responses declined. Ten analgesic drugs were tested for ability to lessen the incidence of abdominal constriction responses within 2 min. of intraperitoneal injection of at least 4 of the 5 challenge substances. Codeine, morphine, cyclazocine, nalorphine, pentazocine, aspirin, flufenamate, meclofenamate and mefenamate were effective to different extents against these challenge substances. Paracetamol was effective only against acetylcholine. All the antipyretic, but none of the narcotic or narcotic antagonist drugs, were more effective against acetylcholine than against tryptamine challenge. Eighty-one drugs were tested as antagonists of abdominal constrictions induced by acetylcholine. All those having analgesic activity in man were effective in the mouse. For 27 analgesic drugs there was a very significant (P