Sex differences in the association between tau PET and cognitive performance in a non-Hispanic White cohort with preclinical AD.
Sex differences in the association between tau PET and cognitive performance in a non-Hispanic White cohort with preclinical AD.
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患有临床前 AD 的非西班牙裔白人队列中 tau PET 与认知表现之间关联的性别差异。
DOI：
10.1002/alz.13432
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
A4StudyTeam
中科院分区：
文献类型：
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作者：
Wang,Xin;Sundermann,ErinE;Buckley,RachelF;Banks,SarahJ;A4StudyTeam
引言我们研究了临床前阿尔茨海默病 (AD) 阶段 tau 蛋白与认知测量之间的关联如何因性别而异。 方法 纳入了来自无症状阿尔茨海默病抗淀粉样蛋白治疗 (A4) 研究的 343 名认知未受损的淀粉样蛋白阳性个体（205 名女性，138 名男性），他们自认为是非西班牙裔白人。我们评估了后颞区 18F-flortaucipir 正电子发射断层扫描 (PET) 标准化摄取值比 (SUVR) 与临床前阿尔茨海默病认知综合 (PACC) 和计算机化认知综合 (C3) 成分之间的性别分层关联。结果我们观察到，较高的 tau 水平仅与女性较差的认知表现显着相关：PACC 及其成分（简易精神状态检查除外） (MMSE) 和 C3 部分：名字首字母回忆 (FNLT) 和单卡学习反应时间 (OCL RT)。除 FNLT 外，这些关联均独立于载脂蛋白 E (APOE) ε4。讨论 女性在临床前 AD 中显示出 tau PET 与认知结果之间更强的关联。这些发现对性别特异性 tau 靶向预防性 AD 临床试验具有重要意义。亮点 颞区 tau 正电子发射断层扫描 (PET) 信号与临床前阿尔茨海默病 (AD) 的认知表现不佳相关。性别分层后，仅在女性中观察到区域 tau PET 与认知结果之间的关联。tau PET 与某些认知结果之间的关联独立于载脂蛋白 E (APOE) ε4。
INTRODUCTIONWe investigated how the associations between tau and cognitive measures differ by sex in the preclinical Alzheimer's disease (AD) stage.METHODSA total of 343 cognitively unimpaired, amyloid‐positive individuals (205 women, 138 men) who self‐identified as non‐Hispanic White from the Anti‐Amyloid Treatment in Asymptomatic Alzheimer's (A4) Study were included. We assessed sex‐stratified associations between18F‐flortaucipir positron emission tomography (PET) standardized uptake value ratio (SUVR) in the meta‐temporal region and Preclinical Alzheimer's Cognitive Composite (PACC) and Computerized Cognitive Composite (C3) components.RESULTSWe observed that higher tau level was significantly associated with worse cognitive performance only in women: PACC and its components except for Mini‐Mental State Examination (MMSE) and C3 components: First Letter Name Recall (FNLT) and One‐Card Learning Reaction Time (OCL RT). These associations except for FNLT were apolipoprotein E (APOE) ε4 independent.DISCUSSIONWomen show stronger associations between tau PET and cognitive outcomes in preclinical AD. These findings have important implications for sex‐specific tau‐targeted preventive AD clinical trials.HighlightsThe tau positron emission tomography (PET) signal in the meta‐temporal region was associated with poor cognitive performance in preclinical Alzheimer's disease (AD).After sex stratification, the associations between regional tau PET and cognitive outcomes were observed only in women.The associations between tau PET and some cognitive outcomes were independent of apolipoprotein E (APOE) ε4.