Stromal micropapillary predominant lung adenocarcinoma: A rare histological phenotype with poor prognosis.
Stromal micropapillary predominant lung adenocarcinoma: A rare histological phenotype with poor prognosis.
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DOI：
10.1002/rcr2.203
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发表时间：
2016-11
影响因子：
0.8
通讯作者：
Funai, Kazuhito
中科院分区：
文献类型：
--
作者：
Hayakawa, Takamitsu;Tajima, Shogo;Tsukui, Masaru;Takanashi, Yusuke;Neyatani, Hiroshi;Funai, Kazuhito
本文报告一例极为罕见的间质微乳头状显性肺腺癌。一位70岁的妇女因胸部X光片显示异常影而来我院就诊。胸部电脑断层显示左下肺叶一结节，左上肺叶一肿块。由于怀疑肺癌晚期，她接受了探查性开胸手术。左下叶结节的病理检查显示肿瘤细胞，超过一半的肿瘤细胞呈间质微乳头状（SMP），由肿瘤细胞侵入纤维化间质组成。通常，肺微乳头状腺癌形成气源性微乳头状模式（AMP），其中肿瘤细胞漂浮在肺泡间隙。由于已知SMP肺腺癌的预后比AMP肺腺癌差，并且表皮生长因子受体突变频率高，因此区分SMP和AMP对病理学家和临床医生都很重要。
An extremely rare case of stromal micropapillary predominant lung adenocarcinoma is presented in this study. A 70‐year‐old woman visited our hospital because of an abnormal shadow on chest X‐ray. Chest computed tomography revealed a nodule in the left lower lobe and a mass in the left upper lobe. She underwent an exploratory thoracotomy owing to the suspicion of advanced lung cancer. Pathological examination of the left lower lobe nodule revealed tumour cells with more than half the tumour cells showing stromal micropapillary pattern (SMP), consisting of tumour cells invading the fibrotic stroma. In general, micropapillary adenocarcinomas in the lung form an aerogenous micropapillary pattern (AMP), in which tumour cells float in alveolar spaces. Because the prognosis of SMP lung adenocarcinomas is known to be worse than that of AMP lung adenocarcinomas and have a high frequency of epidermal growth factor receptor mutations, the discrimination of SMP from AMP is important for both pathologists and clinicians.