Regulation of viral recognition signaling by ubiquitin modification.
Regulation of viral recognition signaling by ubiquitin modification.
复制标题
通过泛素修饰调节病毒识别信号。
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
K. Shimotohno
中科院分区：
文献类型：
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作者：
K. Arimoto;K. Shimotohno
作为对感染的防御机制，宿主细胞已经进化出传感器分子，其直接检测病原体组分并诱导针对感染的保护性反应。TLR是众所周知的受体，识别细胞或内体/溶酶体表面上的病原体。许多病原体渗透到细胞质中，其中非TLR传感器识别病原体组分，包括双链RNA（dsRNA）。在每个传感器的下游，各种功能性信号分子被激活以在微生物入侵时产生各种细胞因子，从而诱导宿主防御反应。由于已知产生的调节宿主防御反应的细胞因子也影响细胞增殖，因此需要严格控制这些分子的水平，这意味着在完成适当的免疫反应后，避免病原体激活的信号传导的负调节。最近的研究表明，一些泛素系统在这一调节中发挥重要作用。在这里，我们重点，特别是泛素缀合信号分子的病毒激活和喜欢显示如何泛素信号在这种调节中发挥作用，通过介绍一些最近的工作。
As a defense mechanism against infection, host cells have evolved sensor molecules which detect pathogen components directly and induce protective responses against the infection. TLRs, well known receptors, recognize a pathogen on the surface of cells or endosome/lysosome. Many pathogens penetrate into cytoplasm, in where non-TLR sensors recognize pathogen components including double-stranded RNA (dsRNA). On the downstream of each sensor, a variety of functional signaling molecules are activated to produce various cytokines upon the microbial invasion to induce host defense responses. Because that cytokines produced to regulate the host defense responses are known to affect cell proliferation also, the level of these molecules are needed to be controlled tightly, which means requisites of negative regulation of the signaling activated by pathogen after the completion of proper immune responses. Recent studies suggest important roles of some ubiquitin systems in this regulation. Here we focus, in particular, ubiquitin conjugation to signaling molecules by virus activation and like to show how ubiquitin signaling plays roles in this regulation by introducing some recent works.
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21.3
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影响因子：
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