Thermal intravascular photoacoustic imaging.
Thermal intravascular photoacoustic imaging.
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DOI：
10.1364/boe.2.003072
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发表时间：
2011-11-01
影响因子：
3.4
通讯作者：
Emelianov S
中科院分区：
文献类型：
--
作者：
Wang B;Emelianov S
血管内光声（IVPA）-一种具有与组织的光学吸收特性相关的对比度的微创成像技术，可用于可视化动脉粥样硬化斑块。然而，光声信号的幅度还与温度相关的组织特异性参数-Grüneisen参数有关。因此，在不同温度下测量的光声信号可以揭示关于组织组成的信息。在这项研究中，热IVPA（tIVPA）成像。使用离体动脉粥样硬化兔主动脉进行成像研究。温度依赖性光声响应斑块和脂质外膜周围组织中的脂质是不同的，从而允许tIVPA图像描绘富含脂质斑块的位置。结果表明，tIVPA成像具有表征动脉粥样硬化血管中组织成分的潜力。
Intravascular photoacoustics (IVPA)—a minimally invasive imaging technique with contrast related to optical absorption properties of tissue, can be used to visualize atherosclerotic plaques. However, the amplitude of photoacoustic signals is also related to a temperature dependent, tissue specific parameter—the Grüneisen parameter. Therefore, photoacoustic signals measured at different temperatures may reveal information about tissue composition. In this study, thermal IVPA (tIVPA) imaging was introduced. The imaging studies were performed using an ex vivo atherosclerotic rabbit aorta. Temperature dependent photoacoustic responses from lipid in plaques and lipid in periadventitial tissue were different, thus allowing tIVPA images to delineate the location of lipid-rich plaques. The results indicate that tIVPA imaging has a potential to characterize tissue composition in atherosclerotic vessels.