THE NUCLEOLUS - AN ORGANELLE FORMED BY THE ACT OF BUILDING A RIBOSOME
THE NUCLEOLUS - AN ORGANELLE FORMED BY THE ACT OF BUILDING A RIBOSOME
复制标题
DOI：
10.1016/0955-0674(95)80085-9
复制
发表时间：
1995-06-01
影响因子：
7.5
通讯作者：
XUE, Z
中科院分区：
文献类型：
--
作者：
MELESE, T;XUE, Z
最近的证据证实了这样一种观点，即核仁的结构不需要严格保持适当的功能，这表明细胞器是由rRNA合成过程中形成的超分子组装体组成的。更有争议的是核仁是否在没有rRNA合成的情况下存在，以及它是否与核支架相互作用。构建核糖体的同时性和高度整合性反映在许多观察结果中，这些观察结果表明参与核糖体生物发生的所有方面的蛋白质都会影响前rRNA加工。几个新的核仁蛋白质的鉴定，没有一个明显的作用，前rRNA代谢可能会提供该领域长期寻求后组装的因素，可能是真核生物核糖体生物发生的关键球员。
Recent evidence corroborates the idea that the structure of the nucleolus need not be strictly maintained for proper function, suggesting that the organelle is composed of supramolecular assemblies formed during rRNA synthesis. More controversial is whether the nucleolus exists in the absence of rRNA synthesis and whether it interacts with the nuclear scaffold. The simultaneous and highly integrative nature of building a ribosome is reflected in the numerous observations showing that proteins involved in all aspects of ribosomal biogenesis affect pre-rRNA processing. The identification of several new nucleolar proteins without an obvious role in pre-rRNA metabolism may provide the field with long sought after assembly factors that might be key players in eukaryotic ribosome biogenesis.