Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review.
Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review.
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DOI：
10.1016/j.ejmech.2017.03.025
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发表时间：
2017-05-26
影响因子：
6.7
通讯作者：
Rawal RK
中科院分区：
文献类型：
--
作者：
Kaur R;Chaudhary S;Kumar K;Gupta MK;Rawal RK
二氢嘧啶是最重要的杂环系，在DNA和RNA的合成中起着重要作用。合成上采用Biginelli反应和Hantzschdihydropyridine等多组分反应合成。在过去的几十年里，由于与这种杂环支架相关的有趣药理特性，这种Biginelli型二氢嘧啶类药物受到了相当多的关注。本文综述了该领域的最新进展，重点介绍了dhpm的抗炎、抗hiv、抗结核、抗真菌、抗癌、抗菌、抗丝虫病、降糖、降压、镇痛、抗抽搐、抗氧化、抗trpa1、抗sars、抗癌活性和α1a结合亲和力等方面的研究进展。本文综述了二氢嘧啶类化合物的合成前景。本文还对二氢嘧啶类化合物的药用前景进行了综述。它包括不同活动的构效关系研究。
Dihydropyrimidines are the most important heterocyclic ring systems which play an important role in the synthesis of DNA and RNA. Synthetically they were synthesized using Multi-component reactions like Biginelli reaction and Hantzschdihydropyridine. In the past decades, such Biginelli type dihydropyrimidones have received a considerable amount of attention due to the interesting pharmacological properties associated with this heterocyclic scaffold. In this review, we highlight recent developments in this area, with a focus on the DHPMs, recently developed as anti-inflammatory, anti-HIV, anti-tubercular, antifungal anticancer, antibacterial, antifilarial, antihyperglycemic, antihypertensive, analgesic, anti-convulsant, antioxidant, anti-TRPA1, anti-SARS, and anti-cancer activity and α1a binding affinity. This review is focused on synthetic prospective of dihydropyrimidinones. This review is also focused on medicinal prospective of dihydropyrimidinones. It includes structure-activity relationship study of different activities.
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