Sodium bicarbonate, an inorganic salt and a potential active agent for cancer therapy
Sodium bicarbonate, an inorganic salt and a potential active agent for cancer therapy
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DOI：
10.1016/j.cclet.2021.06.032
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发表时间：
2021-06
影响因子：
9.1
通讯作者：
Yue Wang;Xueer Zhou;Wenxuan Wang;Yong-Hui Wu;Z. Qian;Q. Peng
中科院分区：
文献类型：
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作者：
Yue Wang;Xueer Zhou;Wenxuan Wang;Yong-Hui Wu;Z. Qian;Q. Peng
癌症因其高死亡率而对人类构成严重威胁。人们为充分了解癌症并与之作斗争所做的努力从未停止过。传统的治疗方法，如手术、放疗和化疗，虽然有效，但不能满足患者日益增长的需求。因此，迫切需要新的抗癌方法。已经发现酸性肿瘤微环境在促进癌症进展中起重要作用。近年来，研究发现碳酸氢钠（NaHCO3）这种简单的无机盐能够逆转肿瘤微环境的pH，抑制肿瘤细胞的侵袭、转移、免疫逃避、耐药和缺氧。因此，以NaHCO3为基础的治疗是一种潜在的治疗癌症的方法，相关的研究报道越来越多。本文旨在全面了解酸性肿瘤微环境，并对NaHCO3在肿瘤治疗中的应用及作用机制进行综述。讨论了NaHCO3与化疗、免疫治疗或纳米颗粒系统的组合。此外，还讨论了NaHCO3在临床应用中的问题以及NaHCO3用于癌症治疗的可能途径。
Cancer is a serious threat to humans due to its high mortality. The efforts to fully understand cancer and to fight against it have never been stopped. The traditional therapies, such as surgery, radiotherapy and chemotherapy, are useful but cannot meet the increasing demands of patients. As such, novel approaches against cancer are urgently required. It has been found that the acidic tumor microenvironment plays important roles in promoting the cancer progression. In recent years, sodium bicarbonate (NaHCO3), a simple inorganic salt, has been found to be able to reverse the pH of tumor microenvironment and inhibit the invasion, metastasis, immune evasion, drug resistance and hypoxia of tumor cells. Thus, NaHCO3-based therapy is a potential approach for the treatment of cancer, and the related studies have been increasingly reported. Herein, we aim to provide a comprehensive understanding of the acidic tumor microenvironment and summarize the applications and mechanisms of NaHCO3in cancer therapy. The combination of NaHCO3with chemotherapy, immunotherapy or nanoparticles systems is discussed. In addition, the concerns of NaHCO3in clinical use and the potential ways to use NaHCO3for cancer therapy are also discussed.