Proton pump inhibitor-associated gastric polyps - A retrospective analysis of their frequency, and endoscopic, histologic, and ultrastructural characteristics
Proton pump inhibitor-associated gastric polyps - A retrospective analysis of their frequency, and endoscopic, histologic, and ultrastructural characteristics
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DOI：
10.1093/ajcp/110.5.615
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发表时间：
1998-11-01
影响因子：
3.5
通讯作者：
Coppola, D
中科院分区：
文献类型：
--
作者：
Choudhry, U;Boyce, HW;Coppola, D
自1992年以来，有报道称质子泵抑制剂与胃底腺型胃息肉有关。这些息肉的内窥镜、组织学特征和自然病史尚未明确，我们对长期使用质子泵抑制剂治疗的胃息肉患者进行了回顾性研究。231例因复杂性胃食道反流病接受2次或2次以上胃镜检查并接受质子泵抑制剂长期治疗的患者中，有17例(男性10例，女性7例，7.3%)发生胃息肉。胃息肉内窥镜检查发现胃息肉后使用质子泵抑制剂的平均间隔为32.5个月。1例患者停止治疗后息肉在3个月内消失。息肉在重新开始治疗4个月后复发，内窥镜检查发现典型的息肉通常很小(
Since 1992 there have been reports of proton pump inhibitors being associated with fundic gland-type gastric polyps. Endoscopic and histologic characteristics and natural history of these polyps have not been clearly defined We performed a retrospective study of patients on long-term treatment with proton pump inhibitors who developed gastric polyps. Gastric polyps developed in 17 (10 males and 7 females, 7.3%) of the 231 patients who underwent 2 or more upper endoscopies for complicated gastroesophageal reflux disease and who were receiving long-term treatment with proton pump inhibitors. The mean interval of proton pump inhibitor use after which an endoscopy revealed gastric polyps was 32.5 months. In I patient discontinuation of treatment resulted in disappearance of the polyps within 3 months. The polyps recurred 4 months after the treatment was restarted Endoscopy established that typical polyps were generally small (