Bone Homeostasis and Repair: Forced Into Shape
Bone Homeostasis and Repair: Forced Into Shape
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DOI：
10.1007/s11926-015-0537-9
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发表时间：
2015-09-01
影响因子：
5
通讯作者：
Leucht, Philipp
中科院分区：
文献类型：
--
作者：
Castillo, Alesha B.;Leucht, Philipp
机械负荷是骨量的有效合成代谢调节剂，而骨质流失的第一道防线是负重运动。同样，受保护的负重是骨科重建手术后第一个规定的物理治疗。在这两种情况下，增强新骨形成都是目标。我们对物理线索、力觉机制以及随后的细胞反应的理解将有助于确定新的物理和治疗方法，以治疗与年龄和废用相关的骨质流失、延迟性骨折和骨不连以及明显的骨缺陷。这篇综述强调了对骨骼在稳态和修复过程中机械适应的原理和机制的重要新见解，并总结了我们目前对骨骼如何适应生物物理力的理解所产生的临床意义。
Mechanical loading is a potent anabolic regulator of bone mass, and the first line of defense for bone loss is weight-bearing exercise. Likewise, protected weight bearing is the first prescribed physical therapy following orthopedic reconstructive surgery. In both cases, enhancement of new bone formation is the goal. Our understanding of the physical cues, mechanisms of force sensation, and the subsequent cellular response will help identify novel physical and therapeutic treatments for age- and disuse-related bone loss, delayed- and nonunion fractures, and significant bony defects. This review highlights important new insights into the principles and mechanisms governing mechanical adaptation of the skeleton during homeostasis and repair and ends with a summary of clinical implications stemming from our current understanding of how bone adapts to biophysical force.