Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
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DOI：
10.1016/s0140-6736(20)30211-7
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发表时间：
2020-02-15
期刊：
影响因子：
168.9
通讯作者：
Zhang, Li
中科院分区：
文献类型：
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作者：
Chen, Nanshan;Zhou, Min;Zhang, Li
背景2019年12月，中国武汉出现了与2019新型冠状病毒（2019-nCoV）相关的肺炎。我们的目的是进一步阐明2019-nCoV肺炎的流行病学和临床特征。方法在这项回顾性、单中心研究中，我们纳入了2020年1月1日至1月20日武汉金银潭医院所有2019-nCoV确诊病例。通过实时RT-PCR确认病例，并分析流行病学、人口统计学、临床和放射学特征以及实验室数据。结果随访至2020年1月25日。结果在99例2019-nCoV肺炎患者中，49例（49%）有华南海鲜市场暴露史。患者的平均年龄为55.5岁（SD 13.1），包括67名男性和32名女性。2019-所有患者均通过实时RT-PCR检测到nCoV。50例（51%）患者患有慢性疾病。患者有发热的临床表现（82例[83%]患者），咳嗽（81例[82%]患者），呼吸短促（31例[31%]患者），肌肉疼痛（11例[11%]患者），意识模糊（9例[9%]患者），头痛（8例[8%]患者），咽喉痛（5例[5%]患者）、腹泻（4例[4%]患者）、胸痛（2例[2%]患者）、腹泻（2例[2%]患者）以及恶心和呕吐（1例[1%]患者）。根据影像学检查，74例（75%）患者表现为双侧肺炎，14例（14%）患者表现为多发性斑点状和毛玻璃样阴影，1例（1%）患者出现气胸。17例（17%）患者发生急性呼吸窘迫综合征，其中11例（11%）患者在短时间内恶化，死于多器官功能衰竭。解读2019-nCoV感染呈聚集性发病，更容易影响患有合并症的老年男性，并可能导致严重甚至致命的呼吸系统疾病，如急性呼吸窘迫综合征。一般来说，死亡患者的特征与MuLBSTA评分一致，MuLBSTA评分是预测病毒性肺炎死亡率的早期预警模型。需要进一步研究以探索MuLBSTA评分在预测2019-nCoV感染死亡风险方面的适用性。版权所有（C）2020爱思唯尔有限公司保留所有权利。
Background In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia.Methods In this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020. Cases were confirmed by real-time RT-PCR and were analysed for epidemiological, demographic, clinical, and radiological features and laboratory data. Outcomes were followed up until Jan 25, 2020.Findings Of the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of exposure to the Huanan seafood market. The average age of the patients was 55.5 years (SD 13.1), including 67 men and 32 women. 2019-nCoV was detected in all patients by real-time RT-PCR. 50 (51%) patients had chronic diseases. Patients had clinical manifestations of fever (82 [83%] patients), cough (81 [82%] patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%] patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two [2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one [1%] patient). According to imaging examination, 74 (75%) patients showed bilateral pneumonia, 14 (14%) patients showed multiple mottling and ground-glass opacity, and one (1%) patient had pneu-mothorax. 17 (17%) patients developed acute respiratory distress syndrome and, among them, 11 (11%) patients worsened in a short period of time and died of multiple organ failure.Interpretation The 2019-nCoV infection was of clustering onset, is more likely to affect older males with comorbidities, and can result in severe and even fatal respiratory diseases such as acute respiratory distress syndrome. In general, characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia. Further investigation is needed to explore the applicability of the MuLBSTA score in predicting the risk of mortality in 2019-nCoV infection. Copyright (C) 2020 Elsevier Ltd. All rights reserved.