Ganglion Cell Loss and Dysfunction: Relationship to Perimetric Sensitivity
Ganglion Cell Loss and Dysfunction: Relationship to Perimetric Sensitivity
复制标题
DOI：
10.1097/opx.0b013e31818b94af
复制
发表时间：
2008-11-01
影响因子：
1.4
通讯作者：
North, Rachel V.
中科院分区：
文献类型：
--
作者：
Drasdo, Neville;Mortlock, Katharine E.;North, Rachel V.
目的.描述两种从外周数据定量神经损伤的方法，并讨论其理论意义。最近发表的模型的视网膜神经节细胞（GC）的感受野密度是用来获得最佳估计的感受野每固体度在每个刺激点的24-2测试图案阵列。提出了一种与年龄相关的变化补偿方法，并利用外周敏感性与GC生存率之间的函数关系来量化损失。提供了右眼24-2测试图案阵列的数据。这些可以根据年龄相关损失进行调整，但也表示为被认为与年龄无关的百分比。简单的模型相关的感受野密度的敏感性提出了定量。方程GC感受野密度在视野中的点的灵敏度的规范性数据，提出了估计GC损失青光眼。如果1/Lambert灵敏度为
Purpose. To describe two methods of neural damage quantification from perimetric data, and to discuss their theoretical implications.Methods. A recently published model of retinal ganglion cell (GC) receptive field density is used to obtain best estimates of the receptive fields per solid degree at each stimulus point in the 24-2 test pattern array. A method of age related change compensation is proposed and a functional relationship between perimetric sensitivity and GC survival is used for loss quantification.Results. Data for the 24-2 test pattern array for the right eye are presented. These can be adjusted for age related loss, but are also expressed as percentages which are considered to be age invariant. Simple models relating receptive field density to sensitivity are proposed for quantification.Conclusions. Equations relating GC receptive field densities at points in the visual field to normative data on sensitivity are proposed to estimate GC loss in glaucoma. If 1/Lambert sensitivity is