Molecular Recognition of Amino Acids by RNA
Molecular Recognition of Amino Acids by RNA
复制标题
RNA 对氨基酸的分子识别
DOI：
10.1007/978-94-011-0754-9_24
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
M. Famulok
中科院分区：
文献类型：
--
作者：
P. Burgstaller;D. Faulhammer;M. Famulok
自从发现遗传密码以来，已经开发了各种关于其起源和进化的模型。其中一个模型基于这样的假设：在原始细胞中存在一组完全随机、高度模糊的密码子分配，编码有限数量的氨基酸（Woese，1965）。由于持续的进化过程，这种模糊的分配变得更加具体，因为“原始”密码子与具有相似侧链的氨基酸组（例如疏水性或芳香性氨基酸）相关联。这些分配的特异性很大程度上取决于氨基酸的“功能重要性”。密码子翻译错误的不断减少最终使这一任务更加符合当今生物学的特殊性。
Since the discovery of the genetic code, various models for its origin and evolution have been developed. One of these models is based on the assumption that in primitve cells a completely random, highly ambiguous set of codon assignments, coding for a restricted number of amino acids, existed (Woese, 1965). As a result of ongoing evolutionary processes this ambiguous assignment grew more specific in the sense that ‘primitive’ codons became associated with groups of amino acids bearing similar side chains (such as hydrophobic, or aromatic amino acids). The specificity of these assignments greatly depended on the ‘functional importance’ of the amino acid. Continuous reduction of errors in codon translation ultimately refined this assignment to the specificity of present day biology.
影响因子：
56.9
作者：
BEAUDRY, AA;JOYCE, GF
通讯作者：
JOYCE, GF
影响因子：
56.9
作者：
PUGLISI, JD;TAN, RY;WILLIAMSON, JR
通讯作者：
WILLIAMSON, JR
DOI：
10.1101/gr.2.1.28
发表时间：
1992-08-01
期刊：
PCR methods and applications
影响因子：
--
作者：
Cadwell, R C;Joyce, G F
通讯作者：
Joyce, G F