Magnetically-actuated artificial cilia for microfluidic propulsion
Magnetically-actuated artificial cilia for microfluidic propulsion
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DOI：
10.1039/c0lc00411a
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发表时间：
2011-01-01
期刊：
影响因子：
6.1
通讯作者：
Onck, P. R.
中科院分区：
文献类型：
--
作者：
Khaderi, S. N.;Craus, C. B.;Onck, P. R.
在本文中，我们定量分析的性能磁驱动的人工纤毛的芯片实验室的应用。利用磁性纳米粒子嵌入聚合物薄膜制备了人工纤毛，并研究了其在不同外磁场和流动条件下的变形。一个耦合的磁-机械固-流体模型，准确地捕捉磁场，纤毛和流体之间的相互作用被用来模拟纤毛运动。纤毛的弹性和磁性的计算模型的结果拟合的实验数据。具有非均匀横截面的人造纤毛的性能的特征在于使用具有实际重要性的两个通道配置的数值模型：开环通道和闭环通道。我们预测，由人造纤毛产生的流量和压头可以分别高达每分钟18微升和3毫米水柱。我们还研究了异时波对产生的流动的影响，并表明，流体推进大幅增加相比，同步跳动纤毛，是单向的。即使相邻纤毛之间的相位差很小，这种增加也是显著的。所得结果为磁驱动微流控推进器人工纤毛的优化设计提供了指导。
In this paper we quantitatively analyse the performance of magnetically-driven artificial cilia for lab-on-a-chip applications. The artificial cilia are fabricated using thin polymer films with embedded magnetic nano-particles and their deformation is studied under different external magnetic fields and flows. A coupled magneto-mechanical solid-fluid model that accurately captures the interaction between the magnetic field, cilia and fluid is used to simulate the cilia motion. The elastic and magnetic properties of the cilia are obtained by fitting the results of the computational model to the experimental data. The performance of the artificial cilia with a non-uniform cross-section is characterised using the numerical model for two channel configurations that are of practical importance: an open-loop and a closed-loop channel. We predict that the flow and pressure head generated by the artificial cilia can be as high as 18 microlitres per minute and 3 mm of water, respectively. We also study the effect of metachronal waves on the flow generated and show that the fluid propelled increases drastically compared to synchronously beating cilia, and is unidirectional. This increase is significant even when the phase difference between adjacent cilia is small. The obtained results provide guidelines for the optimal design of magnetically-driven artificial cilia for microfluidic propulsion.