Host-pathogen interactions in the cornea.
Host-pathogen interactions in the cornea.
复制标题
角膜中宿主与病原体的相互作用。
DOI：
10.1007/s10384-010-0802-4
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发表时间：
2010
影响因子：
2.4
通讯作者：
Gilmore,MichaelS
中科院分区：
文献类型：
--
作者：
Suzuki,Takashi;Yamada,Ai;Gilmore,MichaelS
角膜暴露于结膜囊和环境中的微生物中，但宿主防御系统通常可以预防感染并维持视觉功能。病原体的毒力因子增强了它们引起感染的能力，特别是当眼表受到干扰时，如通过佩戴隐形眼镜、外伤或眼部手术。当表面扰动加上细菌毒力的总和超过宿主清除机制消除微生物的能力时，就会发生感染性角膜炎。因此，了解角膜中病原体和宿主反应之间的动态关系对于预防感染以及开发新的有效治疗和预防措施都是至关重要的。
The cornea is exposed to microorganisms occurring in the conjunctival sac and in the environment, yet host defense systems can usually prevent infection and maintain visual function. Virulence factors of pathogens enhance their ability to cause infection, especially when the ocular surface is perturbed such as through contact lens wear, trauma, or ocular surgery. Infectious keratitis occurs when the sum of surface perturbation plus bacterial virulence exceeds the ability of host clearance mechanisms to eliminate the microbe. Thus, understanding the dynamic between a pathogen and the host response in the cornea is central both to preventing infection and for developing new and effective treatments and prophylaxis measures.