Association of cardiovascular risk factors and endothelial dysfunction in Japanese hypertensive patients: Implications for early atherosclerosis
Association of cardiovascular risk factors and endothelial dysfunction in Japanese hypertensive patients: Implications for early atherosclerosis
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DOI：
10.1291/hypres.25.475
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发表时间：
2002-05-01
影响因子：
5.4
通讯作者：
Kitabatake, A
中科院分区：
文献类型：
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作者：
Furumoto, T;Saito, N;Kitabatake, A
虽然高血压、高脂血症、糖尿病和吸烟是白种人动脉粥样硬化的已知危险因素，但它们对日本人早期动脉粥样硬化的相对作用尚不清楚。肱动脉血流介导的扩张（FMD）减少是内皮功能障碍和早期动脉粥样硬化的有用标志。为了评估高血压对早期动脉粥样硬化形成的相对贡献，我们测定了正常血压和接受治疗的高血压患者的FMD，以及血浆组织型纤溶酶原激活物（t-PA;内皮损伤的敏感指标）、肿瘤坏死因子（TNF）-α和白细胞介素（IL）-6（已确定的炎症标志物）水平。随着危险因素的增加，FMD显著降低，提示危险因素的积累与内皮功能障碍有关。高血压患者的FMD（9.9 ± 5.8（SD）%）较血压正常者（14.6 ± 7.6，p
Although hypertension, hyperlipidemia, diabetes and smoking are known risk factors of atherosclerosis in Caucasians, their relative contributions to early atherosclerosis among Japanese are unknown. Decrease in flow-mediated dilation (FMD) of the brachial artery is a useful marker of endothelial dysfunction and early atherosclerosis. To evaluate the relative contribution of hypertension to early atherogenesis, we determined FMD, as well as plasma levels of tissue-type plasminogen activator (t-PA; a sensitive index of endothelial damage) and tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 (established markers of inflammation) in normotensive and hypertensive patients under treatment. FMD was significantly reduced as the number of risk factors increased, suggesting that accumulations of risk factors were related to endothelial dysfunction. FMD was reduced in hypertensives (9.9+/-5.8 (SD) %) compared to normotensives (14.6+/-7.6, p