The role of CD2AP in the Pathogenesis of Alzheimer's Disease
The role of CD2AP in the Pathogenesis of Alzheimer's Disease
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DOI：
10.14336/ad.2018.1025
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发表时间：
2019-08
影响因子：
7.4
通讯作者：
Qing-Qing Tao-Qing;Yu-Chao Chen;Zhi-Ying Wu
中科院分区：
文献类型：
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作者：
Qing-Qing Tao-Qing;Yu-Chao Chen;Zhi-Ying Wu
阿尔茨海默病（AD）是最常见的神经退行性疾病，其特点是认知能力不可逆下降，发病机制尚不清楚。近年来，越来越多的证据表明，CD2相关蛋白（CD2AP）是一种调节信号转导和细胞骨架分子的支架分子，与AD的发病有关。CD2AP基因的几个单核苷酸多态性（snp）与AD的高风险相关，散发性AD患者外周血淋巴细胞中CD2AP mRNA水平降低。此外，CD2AP功能丧失与Aβ生成增强、tau诱导的神经毒性、神经突结构异常调节和血脑屏障完整性降低有关。本文就近年来有关CD2AP的遗传学和已知功能的研究进展进行综述。综述了近年来有关CD2AP在AD发病机制中的作用的证据，认为CD2AP可能是一个有希望的AD治疗靶点。
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by irreversible decline in cognition with unclear pathogenesis. Recently, accumulating evidence has revealed that CD2 associated protein (CD2AP), a scaffolding molecule regulates signal transduction and cytoskeletal molecules, is implicated in AD pathogenesis. Several single nucleotide polymorphisms (SNPs) in CD2AP gene are associated with higher risk for AD and mRNA levels of CD2AP are decreased in peripheral lymphocytes of sporadic AD patients. Furthermore, CD2AP loss of function is linked to enhanced Aβ production, Tau-induced neurotoxicity, abnormal neurite structure modulation and reduced blood-brain barrier integrity. This review is to summarize the recent discoveries about the genetics and known functions of CD2AP. The recent evidence concerning the roles of CD2AP in the AD pathogenesis is summarized and CD2AP can be a promising therapeutic target for AD.