Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors
Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors
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DOI：
10.1111/j.1468-1331.2004.00976.x
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发表时间：
2005-05-01
影响因子：
5.1
通讯作者：
Mellgren, SI
中科院分区：
文献类型：
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作者：
Omdal, R;Brokstad, K;Mellgren, SI
确定抗人N-甲基-D-天冬氨酸（NMDA）受体NR 2a或NR 2b抗体是否影响系统性红斑狼疮（SLE）患者的神经精神症状。合成了一种十肽，其含有存在于NMDA受体NR 2a和NR 2b的胞外配体结合结构域中的序列基序，该序列基序被单克隆鼠抗DNA抗体R4 A结合。在ELISA与鼠单克隆R4 v作为阳性对照，抗肽（抗NR 2）抗体的57例SLE患者的血浆样品进行了全面的心理和认知测试后，患者进行了检查。视觉配对联想测验（即时）、凹槽钉板测验的表现不佳，以及贝克抑郁量表和MMPI-2量表D-2（抑郁）、Pd-4（精神病性偏离）、Sc-8（精神分裂症）和Ma-9（轻躁狂）的高分，与抗NR 2抗体水平升高显著相关。在几个领域的研究结果表明，抗NR 2抗体和抑郁情绪之间的关联，除了减少短期记忆和学习。因此，NMDA受体抗体可能代表SLE患者脑功能障碍的几种机制之一。
To determine whether neuropsychiatric manifestations in patients with systemic lupus erythematosus (SLE) are influenced by antibodies against the human N-methyl-D-aspartate (NMDA) receptor types NR2a or NR2b. A decapeptide was synthesized containing a sequence motif present in the extracellular ligand-binding domain of NMDA receptors NR2a and NR2b, bound by the monoclonal murine anti-DNA antibody R4A. In an ELISA with the murine monoclonal R4v as positive control, plasma samples of 57 patients with SLE were examined for the anti-peptide (anti-NR2) antibody after the patients had been subjected to comprehensive psychological and cognitive testing. Poor performance on the Visual Paired Associates test (immediate), the Grooved Pegboard test, as well as high scores on the Beck Depression Inventory, and scales D-2 (depression), Pd-4 (psychopathic deviate), Sc-8 (schizophrenia), and Ma-9 (hypomania) of the MMPI-2 were significantly associated with elevated levels of anti-NR2 antibodies. The findings in several domains indicate an association between anti-NR2 antibodies and depressed mood in addition to decreased short-time memory and learning. Antibodies to NMDA receptors thus may represent one of several mechanisms for cerebral dysfunction in patients with SLE.