Cascade synthesis of 1,2-dihydropyridine from dienaminodioate and an imine: a three-component approach
Cascade synthesis of 1,2-dihydropyridine from dienaminodioate and an imine: a three-component approach
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DOI：
10.1016/j.tetlet.2013.05.037
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发表时间：
2013-07-17
影响因子：
1.8
通讯作者：
Lankalapalli, Ravi S.
中科院分区：
文献类型：
--
作者：
Challa, Chandrasekhar;John, Manju;Lankalapalli, Ravi S.
在三氟乙酸介导的一锅级联合成中，由二烯氨基二酸酯和亚胺开发出一种方便的 1,2-二氢吡啶 (1,2-DHP) 合成方法。与这种转化相关的优点包括无金属、室温、未蒸馏溶剂的条件以及快速且产率优异的优点。底物范围已被证明可用于各种芳香族、杂芳香族、不饱和醛、苯胺、苄胺，产率令人印象深刻。 (C) 2013 Elsevier Ltd. 保留所有权利。
A convenient synthesis of 1,2-dihydropyridine (1,2-DHP) has been developed from dienaminodioate and an imine mediated by trifluoroacetic acid in a one-pot cascade synthesis. The advantages associated with this transformation include conditions that are metal-free, room temperature, undistilled solvent, and expeditious in excellent yields. The substrate scope has been demonstrated with various aromatic, heteroaromatic, unsaturated aldehydes, and anilines, benzylic amines in impressive yields. (C) 2013 Elsevier Ltd. All rights reserved.