Euphorstranoids A and B, two highly rearranged ingenane diterpenoids from Euphorbia stracheyi: structural elucidation, chemical transformation, and lipid-lowering activity
Euphorstranoids A and B, two highly rearranged ingenane diterpenoids from Euphorbia stracheyi: structural elucidation, chemical transformation, and lipid-lowering activity
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DOI：
10.1039/d1qo01705e
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发表时间：
2021-12-21
影响因子：
5.4
通讯作者：
Yin, Sheng
中科院分区：
文献类型：
--
作者：
Fang-Yu Yuan;Yue-Hua Pan;Yin, Sheng
大戟甾烷类化合物A（1）和B（2）是从大戟属植物大戟（Euphorbia stracheyi）中分离得到的两个具有5/6/7/3碳环结构的高度重排的二萜烷型二萜化合物。通过光谱、化学和X射线衍射方法的组合确定了它们的结构。1和2的合理的生物合成途径提出和化学模拟。化合物1和2通过在早期阶段延迟细胞脂肪形成而显著抑制3 T3-L1脂肪细胞中的甘油三酯（TG）水平。
Euphorstranoids A (1) and B (2), two highly rearranged ingenane diterpenoids with an unusual 5/6/7/3 carbon ring system, were isolated from Euphorbia stracheyi. Their structures were determined by a combination of spectral, chemical, and X-ray diffraction methods. The plausible biosynthetic pathway of 1 and 2 was proposed and chemically mimicked. Compounds 1 and 2 significantly inhibited the triglyceride (TG) level in 3T3-L1 adipocytes via retarding cell adipogenesis at the early stage.