Creative Destruction: A Basic Computational Model of Cortical Layer Formation
Creative Destruction: A Basic Computational Model of Cortical Layer Formation
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DOI：
10.1101/2020.01.29.921999
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
R. Bauer;G. Clowry;Marcus Kaiser
中科院分区：
文献类型：
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作者：
R. Bauer;G. Clowry;Marcus Kaiser
许多脊椎动物神经系统最具特征的特性之一是不同细胞类型的分层组织。这种细胞结构存在于皮层、视网膜、海马和中枢神经系统的许多其他部分。神经层形成的发育机制已经受到大量的实验努力。在这里，我们提供了一个通用的计算模型，在三维物理空间中的皮层形成。我们表明，这种多尺度，代理为基础的模型，包括两个不同阶段的细胞凋亡，可以解释在不同的皮质区域和物种中遇到的神经元数量的广泛范围。我们的研究结果表明，一个基本的状态图结构的表型丰富，并提出了一个新的功能凋亡。此外，基因调控动力学的轻微变化概括了在神经发育疾病中观察到的特征。总的来说，我们提出了一种新的计算模型，使用基因型规则，表现出许多正常和病理皮质发育的特点。
One of the most characteristic properties of many vertebrate neural systems is the layered organization of different cell types. This cytoarchitecture exists in the cortex, the retina, the hippocampus and many other parts of the central nervous system. The developmental mechanisms of neural layer formation have been subject to substantial experimental efforts. Here, we provide a general computational model for cortical layer formation in 3D physical space. We show that this multi-scale, agent-based model comprising two distinct stages of apoptosis, can account for the wide range of neuronal numbers encountered in different cortical areas and species. Our results demonstrate the phenotypic richness of a basic state diagram structure, and suggest a novel function for apoptosis. Moreover, slightly changed gene regulatory dynamics recapitulate characteristic properties observed in neurodevelopmental diseases. Overall, we propose a novel computational model using gene-type rules, exhibiting many characteristics of normal and pathological cortical development.