Application of carbon nanoparticle/chitosan modified electrode for the square-wave adsorptive anodic striping voltammetric determination of Niclosamide
Application of carbon nanoparticle/chitosan modified electrode for the square-wave adsorptive anodic striping voltammetric determination of Niclosamide
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DOI：
10.1016/j.elecom.2009.10.037
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发表时间：
2010
影响因子：
5.4
通讯作者：
M. Ghalkhani;S. Shahrokhian
中科院分区：
文献类型：
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作者：
M. Ghalkhani;S. Shahrokhian
将纳米碳/壳聚糖膜（CNP/CS）修饰电极用于氯硝柳胺（NA）的电催化还原。采用循环伏安法研究了NA在CNP/CS修饰电极上的电化学行为。研究了NA的还原机理，即硝基的氧化还原机理。研究了实验参数如电位和富集时间、缓冲溶液的pH值和电位扫描速率对电极响应的影响。所制备的复合膜电极稳定性好，均匀性好，响应时间短，重现性好，对NA的电还原具有良好的催化活性，从而显著提高了响应灵敏度。采用方波吸附阳极溶出伏安法（SWAASV）测定NA。在最佳条件下，修饰电极对NA的浓度在0.01-2μM范围内有较宽的线性响应，检出限为7.7nM。该电极用于药物和临床样品中NA的测定，结果满意。
A new modified electrode formed by carbon nanoparticle/chitosan film (CNP/CS) was used for electrocatalytic reduction of Niclosamide (NA). The electrochemical behavior of NA at the CNP/CS modified electrode was investigated in detail by the means of cyclic voltammetry. The reduction mechanism of NA, corresponds to the redox chemistry of nitro group, was thoroughly investigated. The effect of the experimental parameters e.g. potential and time of accumulation, pH of the buffered solutions and potential sweep rate on the response of the electrode was studied. The prepared electrode showed high stability and uniformity in the composite film, short response time, good reproducibility and an excellent catalytic activity toward the electro-reduction of NA leading to a significant improvement in response sensitivity. The square-wave adsorptive anodic stripping voltammetry (SWAASV) was used as an efficient method for the determination of NA. Under the optimal conditions, the modified electrode showed a wide linear response to the concentration of NA in the range of 0.01–2μM with a detection limit of 7.7nM. The prepared electrode was successfully applied for the determination of NA in pharmaceutical and clinical samples and satisfactory results are obtained.