SARS-CoV-2 infection in the Italian Veneto region: adverse outcomes in patients with cancer
SARS-CoV-2 infection in the Italian Veneto region: adverse outcomes in patients with cancer
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DOI：
10.1038/s43018-020-0104-9
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发表时间：
2020-08-01
期刊：
影响因子：
22.7
通讯作者：
Guzzinati, Stefano
中科院分区：
文献类型：
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作者：
Rugge, Massimo;Zorzi, Manuel;Guzzinati, Stefano
在84246名连续接受SARS-CoV-2检测的意大利人中，我们检查了癌症的患病率和病毒感染的临床结果。总体而言，5.7%(4789/84246)以前被诊断为癌症，在SARS-CoV-2阳性(CV2+Ve)患者中，7.8%被诊断为癌症(723/9275)。癌症患病率与感染风险无关(优势比为0.97；95%可信区间为0.89-1.06)。在癌症患者中，CV2+VE患者住院的比例更高(56.6%比34.4%)，死亡比例也更高(14.7%比4.5%)。患有癌症的患者感染SARS-CoV-2的不良后果的风险明显高于非癌症患者，特别是对男性和老年人。Rugge和他的同事报告说，癌症患者，特别是那些年龄较大和男性的患者，面临着显著增加的SARS-CoV-2感染不良后果的风险。
In 84,246 consecutive Italians tested for SARS-CoV-2, we examined the prevalence of cancer and clinical outcomes of viral infection. Overall, 5.7% (4,789/84,246) had previously been diagnosed with cancer and, among the SARS-CoV-2-positive (CV2+ve) patients, 7.8% had a cancer diagnosis (723/9,275). Prevalence of cancer was not associated with risk of infection (odds ratio of 0.97; 95% confidence interval of 0.89-1.06). The proportion of CV2+ve people hospitalized was higher among patients with cancer (56.6 versus 34.4% among other people), and so was the proportion of deaths (14.7% versus 4.5%). The risk of adverse outcomes of SARS-CoV-2 infection was significantly higher for patients with cancer versus those without, particularly for males and older people. Rugge and colleagues report that patients with cancer, particularly those who are older and male, face a significantly increased risk of adverse outcomes of SARS-CoV-2 infection.