Plasma and cavitation dynamics during pulsed laser microsurgery in vivo
Plasma and cavitation dynamics during pulsed laser microsurgery in vivo
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DOI：
10.1103/physrevlett.99.158104
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发表时间：
2007-10-12
影响因子：
8.6
通讯作者：
Ma, Xiaoyan
中科院分区：
文献类型：
--
作者：
Hutson, M. Shane;Ma, Xiaoyan
我们比较了等离子体和空化动力学的基础脉冲激光显微手术在水中和果蝇胚胎（在体内）-特别是纳秒脉冲在355和532 nm。我们发现两个关键的区别。首先，等离子体形成的阈值是较低的体内-特别是在355 nm-由于存在的内源性发色团，作为额外的来源等离子体种子电子。第二，生物基质抑制激光诱导空化气泡的生长。这两种效果减少了破坏区域在体内相比，从水中的测量外推。
We compare the plasma and cavitation dynamics underlying pulsed laser microsurgery in water and in fruit fly embryos (in vivo)-specifically for nanosecond pulses at 355 and 532 nm. We find two key differences. First, the plasma-formation thresholds are lower in vivo -especially at 355 nm-due to the presence of endogenous chromophores that serve as additional sources for plasma seed electrons. Second, the biological matrix constrains the growth of laser-induced cavitation bubbles. Both effects reduce the disrupted region in vivo when compared to extrapolations from measurements in water.