Improving Proton Relaxivity of Dendritic MRI Contrast Agents by Rigid Silsesquioxane Core
Improving Proton Relaxivity of Dendritic MRI Contrast Agents by Rigid Silsesquioxane Core
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DOI：
10.1295/polymj.pj2008274
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发表时间：
2009-01-01
期刊：
影响因子：
2.8
通讯作者：
Chujo, Yoshiki
中科院分区：
文献类型：
--
作者：
Tanaka, Kazuo;Kitamura, Narufumi;Chujo, Yoshiki
我们报道了立方八聚多面体低聚倍半硅氧烷（POSS）的核心树枝状聚合物，新的钆（Gd）螯合剂，增强质子弛豫Gd 3+。Gd与POSS（G1.5）配合物的稳定性与DOTA和DTPA相似。MTT法显示，[Gd 2 POSS（G1.5）]（2-）的细胞毒性低于[Gd（DOTA）]（-）。在MR图像中的检测限比DOTA和DTPA-Gd复合物的检测限提高了约100倍。
We report that the cubic octameric polyhedral oligomeric silsesquioxanes (POSS)-core dendrimers, novel gadolinium (Gd) chelators, enhanced the proton relaxivity to Gd3+. The stability of the Gd complex with POSS(G1.5) was similar to those of DOTA and DTPA. From the MTT assay with the primary hepatocytes, the cytotoxicity of [Gd2POSS(G1.5)](2-) showed lower than that of the [Gd(DOTA)](-) complex. The detection limits were approximately 100-fold improved than those of DOTA and DTPA-Gd complexes in the MR images.