Functional adaptation of human joints to mechanical stimuli
Functional adaptation of human joints to mechanical stimuli
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DOI：
10.1053/joca.2001.0480
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发表时间：
2002-01-01
影响因子：
7
通讯作者：
Putz, R
中科院分区：
文献类型：
--
作者：
Eckstein, F;Faber, S;Putz, R
目的：本研究验证了以下假设：人类关节存在功能适应，关节负荷史的显著差异解释了在人类软骨形态中观察到的表型差异。我们检查了18名铁人三项运动员(9名男性和9名女性)，他们一生都在进行体育锻炼(在过去的3年里，每周训练10小时)，以及18名从未定期进行体育锻炼的志愿者。采用先前验证的脂肪抑制梯度回波MR序列对右膝关节进行成像。结果：膝关节软骨厚度和信号强度在运动员和非运动志愿者之间无显著差异，但男性运动员膝关节表面明显增大(P<0.05)。
Objective: This study tests the hypothesis that functional adaptation occurs in human joints, and that substantial differences in joint 'loading history' explain the phenotypic variability observed in human cartilage morphology.Method. We examined 18 triathletes (nine men and nine women) who had been physically active throughout life (training for >10 h per week for the last 3 years), and 18 volunteers that had never been physically active on a regular basis. The right knee joints were imaged with a previously validated fat-suppressed gradient-echo MR sequence. Cartilage volume, thickness, joint surface areas, and normalized cartilage signal intensity were determined with post-processing software, specifically designed for these applications.Results: The knee joint cartilage thickness, and signal intensity were not significantly different between athletes and inactive volunteers, but male athletes displayed significantly larger knee joint surfaces (P