Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade
Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade
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DOI：
10.1038/nn.2170
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发表时间：
2008-08-01
影响因子：
25
通讯作者：
Montell, Craig
中科院分区：
文献类型：
--
作者：
Kwon, Young;Shim, Hye-Seok;Montell, Craig
在果蝇等动物中，即使环境温度的微小偏差也会对发育和寿命产生重大影响。在这里，我们证明了果蝇幼虫区分最佳温度18摄氏度和稍高温度（19-24摄氏度）的能力取决于TRPA 1通道，该通道在磷脂酶C依赖性信号级联的下游发挥作用，类似于苍蝇光转导中使用的信号级联。我们提出，通过信号级联激活TRPA 1促进放大微小的温度差异，并促进适应舒适范围内的温度。
In animals such as the fruitfly, even minor deviations in environmental temperature can have major impacts on development and lifespan. Here we demonstrated that the ability of Drosophila melanogaster larvae to discriminate between the optimal temperature of 18 degrees C and slightly higher temperatures (19-24 degrees C) depended on the TRPA1 channel, which functioned downstream of a phospholipase C-dependent signaling cascade similar to that used in fly phototransduction. We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range.