Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization
Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization
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DOI：
10.1097/00043426-200411000-00015
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发表时间：
2004-11-01
影响因子：
1.2
通讯作者：
Margolis, DA
中科院分区：
文献类型：
--
作者：
Dincer, AP;Gottschall, J;Margolis, DA
外周血祖细胞（PBPC）现在被广泛用作同种异体移植的祖细胞来源。重组人粒细胞集落刺激因子用于动员PBPC以通过白细胞分离术收集。虽然动员的副作用通常是良性的，但也有不良反应的报道。作者介绍了一例接受PBPC动员的父母供体发生自发性脾破裂（无脾肿大）的病例，回顾了有关该不良事件的文献，并探讨了供体安全性问题。
Peripheral blood progenitor cells (PBPCs) are now widely used as a source of progenitor cells for allogeneic transplantation. Recombinant human granulocyte colony-stimulating factor is used to mobilize PBPCs for collection by leukapheresis. Although side effects of mobilization are generally benign, adverse effects have been reported. The authors present a case of spontaneous splenic rupture, without splenomegaly, in a parental donor undergoing PBPC mobilization, review the literature regarding this adverse event, and explore issues regarding donor safety.